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1 expert is featured in this series.

Dr. Madigan highlights the evolving treatment landscape by discussing promising clinical trial data for second-generation KIT inhibitors, like bezaclastinib and elenestinib, which offer high selectivity and limited CNS penetration. She reinforces the "practice pearl" that nearly all adults with fixed skin lesions have systemic disease, emphasizing that these lesions are distinct from transient hives and require lifelong vigilance.

Experts featured in this series.

In this episode, the panelists explore the baseline characteristics of the STOP HS trials and why they matter for interpreting the results and applying them to practice. They first emphasize the achievement of running a >1,200‑patient, global phase 3 HS program, urging clinicians everywhere to refer patients to clinical trials to keep building robust data.