Aaron Farberg, MD; Tina Bhutani, MD, MAS; Christopher Bunick, MD, PhD; and Harrison Nguyen, MD, MBA, MPH, explore the complex challenges of identifying, treating, and managing generalized pustular psoriasis—a rare, potentially life-threatening condition characterized by widespread sterile pustules—discussing its profound quality-of-life impact, common triggers, evolution of treatments from traditional systemics to targeted biologics, clinical cases highlighting emergency management and maintenance approaches, and promising future directions in diagnostics and personalized therapies.
