Skin Cancer

In part 1 of this Frontline Forum series, Brent Moody, MD; Sarah Arron, MD, PhD; Justine Cohen, DO; Emily Ruiz, MD, MPH; and Todd Schlesinger, MD, discuss non-surgical treatment options for the management of BCC, dose adjustments for systemic treatments, combining hedgehog pathway inhibitors with immunotherapy, and more.

Rescue workers had a higher rate of malignant melanoma between 2005 and 2015 compared the general population of New York State.

Second-line end points of the TRICOTEL trial assessing atezolizumab plus vemurafenib and cobimetinib in melanoma with central nervous system metastases appear consistent with primary efficacy end points.

A coprimary end point in the phase 3 LEAP-010 study will not be met.

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Melanoma cases were almost 10 times higher in high Human Development Index countries than in low.

In this week’s Pointers With Portela, the 208SkinDoc takes an in-depth look at Merkel cell carcinoma after Jimmy Buffett passed away from a 4-year battle with the rare form of skin cancer.

Endocrine toxic effects were more likely than nonendocrine to become chronic and continue at last follow-up.

Risk of recurrence or death was reduced by 58% compared to placebo.

Collaboration between dermatologists and gynecologists can improve patient quality of life and outcomes in vSCC treatment.

According to study authors, this electrical communication between skin cells may have the potential for therapeutic implications.

Although rare, clinicians are encountering more pediatric patients who are at an increased risk of skin cancer due to immunosuppression.

A combined treatment regimen of encorafenib and binimetinib led to improved progression-free survival, overall response rate, and tolerability in patients with advanced BRAF-mutant melanoma.

Patients with the DecisionDx-Melanoma 31-gene expression profile test had a 29% lower melanoma-specific survival mortality.

Most of the patients receiving the non-surgical treatment experienced a complete clearing of tumors.

While the linkage between squamous cell cancers and genital lichen sclerosus has been well-established, fewer studies have examined the associations between penile melanomas in males.

The study is the first large study to assess skin cancer screening efforts aimed at volunteer firefighters in the US.

Research showed that many patients with skin cancer who had been treated using immunotherapy, such as immune checkpoint inhibition, experienced chronic side effects.

Clinically asymptomatic patients receiving alternative to conventional follow-up had a higher 3-year overall survival rate.

In this week’s Pointers With Portela, the 208SkinDoc answers frequently asked questions about sunscreen use.

"The analysis showed a statistically significant, positive effect of normal serum vitamin D levels on increasing ORR and PFS as a result of anti-PD‐1 immunotherapy in patients with locally advanced inoperable or metastatic melanoma,” according to a recent study.

The phase 1 study evaluated patient responses to cosibelimab in cases of locally advanced or metastatic cutaneous squamous cell carcinoma.

Respondents did not know how long they needed to be outside to get adequate vitamin D.

In ethnic and racial minority populations, more than 12,000 standard skin cancer screenings would be done to identify 1 case of melanoma, according to a recent study.

Study finds that use of mHealth app could be useful in early detection of skin cancer but cautions that overdiagnosis is a possibility.

Researchers found significant difference in survival rates between lentigo maligna melanoma, nodular malignant melanoma, and superficial spreading melanoma.

Both companies are hoping to make a positive impact in the neoadjuvant setting of cutaneous squamous cell carcinoma.

V940-001 is the first phase 3 study of a planned comprehensive clinical development program initiated after the positive primary analysis of the phase 2b KEYNOTE-942/mRNA-4157-P201 trial.

Men have a lower overall survival rate than women when diagnosed with melanoma.

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