Drs. Peter Lio and Alexandra Golan discuss a recent expert consensus paper examining the risks associated with topical and systemic corticosteroid use and the evolving role of advanced targeted topical therapies in inflammatory dermatoses. Throughout the discussion, the faculty review evidence on corticosteroid-related adverse events, treatment burden, and the challenges of long-term disease management, while emphasizing the importance of corticosteroid stewardship and individualized patient care. The panel also explores the growing body of safety and efficacy data supporting nonsteroidal topical therapies and their role in achieving durable disease control, reducing reliance on chronic corticosteroid use, and supporting proactive treatment strategies. Finally, the faculty highlight practical considerations for incorporating these therapies into clinical practice, including patient selection, access, affordability, and overcoming barriers to adoption.