Tolerability and Benefits of Natural Moisturizing Factor–Containing Products

A recent study examined the effects of a moisturizing cream applied once daily for 4 weeks on 40 participants. Both trained investigators and subjects assessed tolerability and efficacy, focusing on visual dryness, surface roughness, radiance, and fine lines. After 4 weeks, improvements were noted across all these parameters. Remarkably, even after a 3-day regression period without product use, hydration and skin quality benefits persisted, indicating the moisturizer’s ability to strengthen and optimize the skin barrier beyond just surface effects. This type of assessment highlights the lasting physiological impact of a well-formulated moisturizer.

Further studies evaluated 2 different products: a lighter gel moisturizer and a richer cream moisturizer. The gel was designed for combination or acne-prone skin, while the cream targeted those with skin diseases such as eczema or rosacea. The gel moisturizer was found to significantly reduce skin sensitivity and was well tolerated by patients with oily or combination skin. This is particularly important for patients with acne who need barrier repair without exacerbating oiliness or acne symptoms. The cream moisturizer, containing natural moisturizing factors and lipids, showed improvements in noxious sensory symptoms, skin smoothness, radiance, and overall appearance after 4 weeks, making it suitable for patients with dry or compromised skin conditions.

When recommending moisturizers, factors such as skin type and sensitivity guide ingredient choices. Humectants like glycerin and hyaluronic acid are favored for hydration, while niacinamide can help soothe inflammation. For patients with eczema or very dry skin, richer creams or ointments with ceramides and occlusive lipids are preferred. For acne-prone skin, noncomedogenic formulas that maintain the skin barrier without clogging pores are essential. Patients with rosacea benefit from fragrance-free, soothing ingredients such as allantoin to avoid irritation and redness. Customizing moisturizer recommendations based on skin condition ensures optimal results and better patient adherence.