Amy Lewis, MD, on Glo2Facial's Multi-Technology Approach and the Power of Internal Oxygenation

In a recent interview with Dermatology Times, Amy Lewis, MD, a New York-based cosmetic dermatologist and clinical associate professor at Yale University, shared insights into the Glo2Facial device, a multi-technology platform that has significantly enhanced her aesthetic practice. The unique device combines 4 synergistic technologies for the first time: patented Oxfoliation and RF Pro (radiofrequency), along with ultrasound and detox massage. Lewis emphasized its flexibility, allowing clinicians to tailor treatments according to individual patient needs, skin conditions, and even seasonal changes.

Central to the Glo2Facial is its Oxfoliation technology, based on the Bohr Effect, which draws oxygen from within the skin to the surface, unlike conventional systems that apply oxygen externally. This internal oxygenation promotes cellular health and nutrient delivery, enhancing overall skin function. The RF Pro component supports collagen, elastin, and hyaluronic acid production, making it ideal for long-term skin rejuvenation and tightening, especially when used repeatedly.

“It's something that is great for your skin to do for health reasons, but also it makes you feel better,” Lewis tells her patients, “Your confidence is better, and you just look better when you look in the mirror.”

The device also offers 7 customizable treatment “booster” options: Hydrate, Protect, Energize, Firm, Brighten, Refine, and Smooth. These allow dermatologists to target specific concerns such as dryness, hyperpigmentation, inflammation, or texture irregularities. Lewis particularly noted its popularity for “red carpet ready” treatments at her NYC practice, delivering both visible radiance and improved skin function in a relaxing, spa-like experience.

Ideal candidates range widely—from aesthetic newbies seeking gentle yet effective skin initiation, to seasoned patients integrating the Glo2Facial alongside injectables or lasers to optimize outcomes. With no downtime and notable increases in skin oxygenation (up to 23%), the non-invasive treatment serves as both a standalone therapy and an adjunct to more invasive procedures.

“I think anybody who has skin is a great candidate,” Lewis said.

She also highlighted its expanding role in body treatments, especially for patients experiencing skin laxity from weight loss or GLP-1 medications. Areas such as the abdomen, arms, and neck are seeing measurable improvements in tone and firmness with repeated sessions.

“You don't want to tell someone’s age from their neck or their hands. So always look at these adjunct areas and treat them also,” Lewis reminded.