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All surgical management of melanoma is defined by Breslow thickness. For melanoma less than 1 mm in thickness, typically a SLNB is not required. Future imaging devices may better delineate the extent and depth of the tumor in vivo.

Genetic profiling is valuable in both diagnosis and prognosis of skin cancer. Hedgehog inhibitors and (superficial radiation therapy) SRT are strong contenders for treating nonmelanoma skin cancer. Advances in targeted therapies and biologics are part of the new wave of melanoma treatments.

The big squeeze

Limited provider networks are cutting more than costs; these narrow networks are cutting dermatologists. One expert shares insight on what derms need to know.

Norman Levine, M.D., notes that being a physician is not easy. A large part of the difficulty centers on the patient-doctor relationship and how one maximizes the benefits that the patient accrues by the care he receives.

Instructional handouts help caregivers stick to complicated treatment plans for pediatric AD patients. Historically effective AD treatments are being augmented with new phosphodiesterase inhibitors and biologics. Gentler approaches such as massage, light therapy, and melatonin may also be of value for children with AD.

Drugs to treat atopic dermatitis are at the top of the FDA’s dermatology list. Biologics and PDE4 inhibitors show promise in the treatment of AD. Approval is still needed for the use of biologics to treat AD in pediatric patients.

With a long history in dermatology and rheumatology, TNF inhibitors can not only improve psoriasis and psoriatic arthritis, but they also may reduce comorbid cardiovascular risks and work better combined with methotrexate. Low doses of cyclosporine may be effective at treating the psoriasis reaction when topicals have proven ineffective. Aggressively managing TNF-induced reactions can help patients stay on drugs that are working for other challenging diseases.

Dermatologists should be versed and informed about the specific attitudes and lifestyle habits that could be fueling rising skin cancer risk in the Hispanic population, according to dermatologist Maritza I. Perez, M.D.

Cyclosporine and PUVA clearly increase the risk of squamous cell carcinomas, and there is evidence that TNF blockers and methotrexate may do so to a lesser degree. UVB phototherapy has not been shown to cause skin cancer. Acitretin offers protection against the development of basal cell and squamous cell carcinomas.

Patients who carry a high-penetrance melanoma predisposition gene can often benefit from screening for other cancers. Patients who receive a positive genetic test result are more likely to embrace prevention and detection measures. A new “Rules of Three” proposes a point-based guideline to help determine who should be referred for genetic counseling and testing.

The American Joint Committee on Cancer (AJCC) 8th Edition Melanoma Staging System includes important changes pertaining to T1 melanomas. The role of sentinel lymph node biopsy (SLNB) continues to evolve, particularly for thin melanomas. A contemporary international dataset is being applied to develop sophisticated and accurate personalized prognostic tools.

The American Joint Committee on Cancer (AJCC) 8th Edition Melanoma Staging System includes important changes .

About one third of the more than 118,000 people who received free skin cancer screenings from the AAD’s SPOTme program in 2009 and 2010 indicated they had recently seen a change in the size, shape or color of a mole.

When it comes to choosing topical agents for treating acne, separating fact from fiction can be challenging for dermatologists.

Studies suggest that a more aggressive approach to neck tightening procedures yields better results. Patients can experience significant pain and edema from these procedures that may require prescription medications to treat. The procedures cost thousands of dollars, raising questions about whether they're worth the cost for patients.

Picking the best peel

Many different types of peels are available to successfully treat a wide variety of skin conditions. Instances of post-inflammatory hyperpigmentation (PIH) that develop after healing of peel or laser treatments may require additional management. Attendance at workshops and use of prepackaged kits can help derms gain confidence in providing peel treatments to patients.

Emerging treatments are expected to help fill the need for safer and more effective therapies for atopic dermatitis (AD). Both systemic and topical treatments are needed to provide full and complete treatment for patients with AD. Targeting the specific axis or axes that control AD may contribute to developing personalized approaches to treatment

TNF inhibitors adalimumab and infliximab have evidence-based efficacy for the treatment of hidradentitis suppurativa (HS). Anti-interleukin inhibitors ustekinumab and anakinra also being evaluated in small studies for treatment of HS. Antibiotics, hormones, retinoids, steroids and laser therapies directly targeting the lesions round out an effective treatment plan for HS patients.

Biosimilars have the potential to lower the high costs of biologic treatments for patients suffering from chronic skin diseases. Although biosimilars have received FDA approval derms still have many questions about what they are and when they may be used appropriately. Patent wars and a lack of rules and regulations at the state level add to the confusion about using biosimilars.