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Panelists discuss how the primary endpoint of the Effisayil 2 trial focused on the time to first GPP flare, while secondary endpoints assessed flare severity, quality of life, and inflammatory markers, providing a comprehensive evaluation of spesolimab's impact on GPP management.

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James Song, MD, discusses how clinical trial data demonstrates the risk-benefit profile of vitiligo therapies, with particular focus on balancing potential adverse effects of Janus kinase inhibitors against their proven efficacy in achieving repigmentation.

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James Song, MD, discusses how Janus kinase (JAK) inhibitors represent a breakthrough in vitiligo treatment by effectively targeting the immune pathways responsible for depigmentation, offering patients a powerful new therapeutic option with promising repigmentation results.

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Gina Mangin, MPAS, PA-C, discusses how measuring atopic dermatitis treatment success requires evaluating multiple factors, including reduction in itch intensity, improvement in sleep quality, decreased flare frequency, enhanced quality of life, and visible skin healing through standardized assessment tools and patient-reported outcomes.

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Gina Mangin, MPAS, PA-C, discusses how identifying atopic dermatitis triggers involves carefully tracking patient exposure to common irritants such as soaps, fabrics, allergens, stress, and environmental factors while monitoring symptom flare-ups to develop targeted prevention strategies.

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Gina Mangin, MPAS, PA-C, discusses how developing an effective atopic dermatitis treatment plan requires a personalized, multifaceted approach that combines proper skin care, trigger avoidance, topical medications, and potentially systemic therapies based on the severity of symptoms and individual patient needs.

Panelists discuss how spesolimab dosing regimens are tailored to individual patient needs, with an initial high-dose infusion followed by maintenance therapy based on clinical response and disease severity.

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Andrew Alexis, MD, MPH, discusses how, in creating individualized treatment plans for vitiligo, clinicians must carefully consider the distinct challenges and response patterns associated with segmental vs nonsegmental forms, as segmental vitiligo tends to be more stable after initial progression but often more resistant to treatment, while nonsegmental vitiligo typically shows a more unpredictable course requiring ongoing management strategies.

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The panelist discusses the primary challenges in vitiligo repigmentation, including maintaining patient compliance through lengthy treatment courses and managing expectations around partial repigmentation outcomes, which require careful monitoring and ongoing patient education about realistic goals while assessing success through standardized documentation of even minimal improvements to inform treatment adjustments.

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Andrew Alexis, MD, MPH, discusses how holistic management of vitiligo requires addressing both the physical and psychological impact through empathetic counseling and support groups while setting realistic treatment expectations and timelines with patients through clear communication about repigmentation goals, potential outcomes, and available therapeutic options.