Long-Term Management Strategies in cSCC

In “Long-Term Management Strategies in cSCC,” our panel explores approaches to surveillance, recurrence prevention, and long-term management for patients with high-risk and advanced cutaneous squamous cell carcinoma (cSCC). The expert faculty discuss how patient education, behavioral modification, and personalized follow-up schedules play a critical role in improving outcomes and supporting early detection of recurrent disease.

The panel reviews practical strategies used in clinical practice to help patients recognize concerning skin changes, perform self-examinations, and adopt ongoing sun protection measures following a diagnosis of high-risk cSCC. The expert faculty emphasize the importance of counseling patients regarding their elevated lifetime risk of developing additional cSCC lesions and the need for continued dermatologic surveillance.

Additionally, the discussion highlights how gene expression profiling (GEP) may help refine follow-up intensity and recurrence monitoring. The panelists discuss how molecular risk information can support decisions regarding surveillance frequency, particularly for patients with elevated recurrence risk or limited access to dermatologic care. The expert faculty also examine how GEP may help identify patients who require closer longitudinal monitoring and earlier intervention for recurrent disease. Throughout the episode, the panel underscores the importance of combining patient-centered education, multidisciplinary care, and precision medicine tools to optimize long-term management strategies in cSCC.

Our next episode, “Guidelines and Precision Medicine in cSCC,” explores future directions in molecular profiling, including emerging evidence for neoadjuvant immunotherapy, evolving treatment strategies, and opportunities to further personalize care for patients with cSCC.