
Kona, Hawaii - Tacrolimus ointment is superior to pimecrolimus cream in treating atopic dermatitis, according to recent trial data reported by Alan Fleischer, M.D., during the 28th Annual Hawaii Dermatology Seminar here. Both calcineurin inhibitors have identical modes of action and identical metabolism, and bind to the same FKBP receptor. "But pimecrolimus has one-third the binding affinity of tacrolimus," he says.
