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San Francisco - A one-week course of oral valacyclovir (Valtrex) appears to be a safe, effective, and economical alternative to inpatient or outpatient intravenous (IV) acyclovir (Zovirax) for treatment of immunocompromised patients with uncomplicated, acute herpes zoster virus infections, Mathijs H. Brentjens, M.D., said at the annual meeting of the American Academy of Dermatology.