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Understanding Clascoterone Cream: MOA, Patient Selection Criteria, and Gender-Inclusive Advantages


Continuing the discussion on the case of a 17-year-old patient with moderate acne, Heather Woolery-Lloyd, MD, FAAD, provides an overview of the utilization of clascoterone cream, highlighting the application process and its unique mechanism of action.

Video content above is prompted by the following questions:

•In your opinion, what aspects of clascoterone’s unique MOA could be emphasized to the patient to differentiate it from other topical/previously utilized treatments? What is the importance of this treatment targeting androgen receptors? How does this differ from other from other anti-androgens?

•Why is clascoterone cream typically prescribed for twice-daily application? How does the rapid metabolism of clascoterone influence its dosing frequency?

•When advising patients on clascoterone cream, do you suggest applying it all over the affected area or spot treating specific lesions? Please explain the rationale behind targeting clascoterone activity at the sebum level and the importance of covering the entire affected area to inhibit acne development

•Do you believe it's worthwhile to define an optimal patient profile for clascoterone use? If so, what characteristics would you include in this profile?

•Are there any differences in your approach to prescribing clascoterone between male and female patients? Do you have any concerns for the utilization in males?

•Can you share your experiences or considerations when using clascoterone in patients with specific skin types or conditions, such as patients with skin of color or underlying dermatologic conditions?

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