Promising topical agents for psoriasis and/or atopic dermatitis (AD) that are commercially available or in late-stage development include tapinarof, JAK inhibitors, phosphodiesterase (PDE) inhibitors and combination products with novel patient-friendly vehicles.
In dealing with inflammatory dermatoses, says George Han, M.D., Ph.D., a patient’s desire for nonsteroidal topical treatments fits into an overall trend toward products perceived as natural. He is an assistant professor of dermatology at the Icahn School of Medicine at Mount Sinai in New York.
However, he noted, patients should beware of Internet “miracle” products. When a colleague had a purported herbal cream brought in by a patient analyzed, its main ingredient was clobetasol.
Fortunately, says Dr. Han, an increasing number of nonsteroidal treatments for psoriasis and AD are becoming available. For starters, he says, many dermatologists are excited about tapinarof.
“Technically it is a natural product, which may satisfy picky patients who only want natural remedies,” he says.
Tapinarof is a small molecule produced by bacteria that live off of nematodes.
In AD, which is expected to be tapinarof’s first indication, the drug has posted efficacy numbers more impressive than those of the PDE4 inhibitor crisaborole.
Dr. Han has been an advisor for Intraderm, Janssen, UCB and Eli Lilly; an investigator for MC2 Therapeutics; a speaker for Sun Pharma; an investigator and speaker for Pfizer; and an advisor and speaker for Sanofi Regeneron.
George Han MD. “New and Upcoming Topicals in Psoriasis and Atopic Dermatitis,” Atlantic Dermatological Conference. May 5, 2019. New York.
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