Curcumin has a long history as an effective treatment for everything from chronic pain to skin infections. Nanoparticle encapsulation shows promise in meeting that challenge and opening the way for a safe, effective adjuvant to sunscreen.
“We hypothesize that when a stable formulation is effectively delivered through the skin, curcumin modifies gene expression of inflammatory cytokines, alters downstream cytokine production, limits acute DNA damage, and ultimately attenuates the inflammatory and apoptotic response to UVB radiation,” the authors wrote. “Further investigation into applications alongside sunscreens against UV-induced cellular damage, oxidative stress, and inflammation is warranted.”
The authors reported no relevant disclosures.
1. Adusumilli NC, Mordorski B, Nosanchuk J, Friedman JM, Friedman AJ. Curcumin nanoparticles as a photoprotective adjuvant. Exp Dermatol. 2021;30(5):705-709. doi:10.1111/exd.14282
2. Zhang Z, Leong DJ, Xu L, et al. Curcumin slows osteoarthritis progression and relieves osteoarthritis-associated pain symptoms in a post-traumatic osteoarthritis mouse model. Arthritis Res Ther. 2016;18(1):128. doi:10.1186/s13075-016-1025-y
3. Krausz A, Gunn H, Friedman A. The basic science of natural ingredients. J Drugs Dermatol. 2014;13(8):937-943.
4. Draganski A, Tar MT, Villegas G, Friedman JM, Davies KP. Topically applied curcumin-loaded nanoparticles treat erectile dysfunction in a rat model of type-2 diabetes. J Sex Med. 2018;15(5):645-653. doi:10.1016/j.jsxm.2018.03.009
5. Tsai KD, Lin JC, Yang SM, Tseng MJ, et al. Curcumin protects against UVB-induced skin cancers in SKH-1 hairless mouse: analysis of early molecular markers in carcinogenesis. Evid Based Complement Alternat Med. 2012;2012:593952. doi:10.1155/2012/593952