PDE4 Inhibitor Roflumilast for AD

Key Takeaways

• The evolution of atopic dermatitis treatments emphasizes nonsteroidal options, reducing corticosteroid dependency and targeting specific inflammatory pathways.
• Nonsteroidal treatments, like PDE4 inhibitors, offer effective modulation of immune responses with a favorable side effect profile.
• PDE4 inhibitors increase intracellular cAMP levels, downregulating pro-inflammatory cytokine production and targeting atopic dermatitis inflammation.