News

I have grown accustomed to thinking that I probably know more about myself than anyone else. After all, I am me, and, as such, I am the foremost expert on myself. How could anyone possibly know more?

San Francisco - Individualization of drug therapy is becoming a reality with the recognition that the response to drugs varies as a result of sequence variants in genes encoding drug-metabolizing enzymes, drug transporters, or drug targets.

San Francisco - The topical immunomodulators imiquimod (Aldara), tacrolimus (Protopic), and pimecrolimus (Elidel) are proving to be extremely useful agents for the effective management of a number of skin conditions, Mark Lebwohl, M.D., said at the annual meeting of the American Academy of Dermatology.

Ottawa - Dermatologists have a responsibility to sensitize patients to the risks that temporary tattoos and body piercing pose, according to Dr. Ronald Brancaccio, clinical professor of dermatology at New York University School of Medicine, who presented here at the annual scientific meeting of the Canadian Dermatology Association.

With only 10 official SARS patients throughout China since August 1, the word of eradication is becoming hopeful in a country where Severe Acute Respiratory Syndrome seems like a bad dream. But, the reality is that SARS may be an unstoppable nightmare.

A CME monograph sponsored by The Institute for Medical Studies and Advanstar Healthcare Communications. Supported by an unrestricted educational grant from Amgen Inc. and Wyeth Pharmaceuticals.The views and opinions expressed are those of the interviewed physicians and do not necessarily reflect the views of the editors, Advanstar Healthcare Communications. The Institute of Medical Studies, Amgen Inc., or Wyeth Pharmaceuticals. For faculty, and learning objectives please download this PDF file.

Current therapies for psoriasis can be very effective and are acceptable to many patients. However, a number of drawbacks associated with these treatments may compromise their effectiveness. Patients undergoing ultraviolet B (UVB) phototherapy or psoralen plus ultraviolet A (PUVA) treatments must keep their appointments 3 times a week to maintain the effectiveness of the therapy.

The class of agents known as TNF inhibitors shares some common safety issues, but the safety profiles of specific agents vary due to differing characteristics and mechanisms. Comparing safety data of these drugs is, of course, complicated by differences in patient populations and experiences.

These are very exciting times for dermatology. Basic research is being applied to the development of new and more effective biologics to treat some of the most challenging conditions, psoriasis among them.

Over the past couple of years wireless technology for connecting laptops and other computers to local area networks and the Internet has matured and become affordable. Now, for less than $100, a wireless network card can be installed in most laptop or desktop computers, affording the machines a high-speed connection to wireless access points.

Washington - By eating foods with a low glycemic index, patients can reduce the rate at which wrinkles develop in the skin and accelerate postoperative healing.

San Francisco - Providing patients with the best service mandates dermatologic surgeons become comfortable and skilled in diagnosing and managing post-op complications, Hugh M. Gloster Jr., M.D., said.

San Francisco - Making laser surgery as pleasant an experience as possible is important when the patient is a child because optimal clearing of many common pediatric lesions treated with a laser involves multiple sessions, Heidi A. Waldorf, M.D., said at the annual meeting of the American Academy of Dermatology.

Barcelona - Until now, scientists have known that estrogens significantly affect the hair cycle in rodents, although disparities have lingered as to the hormone's impact on human hair.

Barcelona - Ebastine, a second-generation antihistamine currently marketed in Europe and Japan, offers many advantages as a treatment for mild to moderate alopecia areata, according to Yusuke Yoshizawa, M.D., assistant professor of dermatology, Nippon Medical School, Tokyo.

San Francisco - Designed to treat difficult cases of cutaneous T-cell lymphoma, photopheresis is proving to have several more potential clinical applications, including graft-versus-host disease (GVHD) and lichen planus.

Chicago - The promise of biochemotherapy for stage IV malignant melanoma has not held up to scrutiny, and the value of this form of treatment seems nil, according to recent discouraging findings from major phase III clinical trials.

Chicago - Escalating doses of an antibody to CTLA-4 in conjunction with a peptide vaccine showed the induction of antigen-specific immune responses and potential evidence of autoimmunity in patients with stage III/IV resected melanoma, according to Jeffrey M. Weber, M.D., Ph.D.

Chicago - In the early days before protease inhibitors, Kaposi's sarcoma was considered a severe and dangerous ancillary condition that often was fatal to patients.

Chicago - A phase II trial of a new recombinant agent in the fight against melanoma has accrued 28 patients so far, yielding interesting data but so far no conclusive results, according to an abstract presented at this year's annual meeting of the American Society of Clinical Oncology.

Chicago - As patient accrual to phase III trials of Canvaxin therapeutic polyvalent cancer vaccine nears the 1,000-mark, a randomized phase II trial of the vaccine was reported at the annual meeting of the American Society of Clinical Oncology. The trial used an immunostimulant to enhance the antibody response to a tumor-associated antigen (TA90) found on melanoma cells.

Chicago - Data involving the first 60 patients in a phase II clinical trial of a multi-epitope peptide vaccination, as combined with other agents, showed a median survival of 21 months for immunological responders as compared to 13 months in immunologic nonresponders.

San Francisco - The future of melanoma treatment may include a union of surgical and medical oncology in which treatments such as interferon play an important role, according to Donald P. Lawrence, M.D. However, it is less likely that melanoma treatment will evolve to include genetically targeted therapies such as imatinib (Gleevec) in the future.

Maui, Hawaii - Applied in a foam, ketoconazole may penetrate more easily -- and treat cutaneous fungal infections more effectively - than it does in the cream formulations currently on the market, Dr. Sheila Fallon-Friedlander, M.D.

San Francisco - Although bacterial sexually transmitted diseases are decreasing in prevalence in the United States, viral STDs are on the rise, according to Ted Rosen, M.D. Of particular concern, he said, are the increasing numbers of people infected with herpes simplex virus (HSV) and human papilloma virus (HPV).

San Francisco - Accumulating evidence suggests new biologic agents may be used with potential benefit in the management of dermatomyositis, pyoderma gangrenosum, bullous diseases, cutaneous sarcoidosis, and severe atopic dermatitis.Dermatologists, however, have also been looking to use various older therapies in new ways to treat these disabling diseases, Jeffrey P. Callen, M.D., said.

Americans are getting barely half of the appropriate medical care they should be getting - that's the analysis of a study released recently in the New England Journal of Medicine. Through patient interviews and reviews of medical records of 30 medical conditions for thousands of patients in 12 metropolitan centers around the country, researchers determined that patients get the appropriate care just 54 percent of the time. That percentage can vary from 40 percent for alcohol dependency to 78 percent for senile cataracts.

Ottawa - Ethical issues in medicine are not that different across practice specialties, and ultimately, physicians should be acting with the interests of their patients first and foremost, according to a professor in the department of dermatology and the departmental chair at Mayo Clinic, Scottsdale, Ariz.

Dr. Sun runs a large medical and cosmetic dermatology practice in a moderately wealthy, middle-class Sun Belt community. A large portion of his practice base is above the age of 65. Many of these patients present with a variety of skin cancers. The same patients seek cosmetic treatments with lasers, peels, botulinum toxin, and filler agents. Dr. Sun finds that treating the sola-induced comedones in these patients is not cost-effective. Thus, he gives gratis comedone extractors to his combined medical-surgical patients. He finds that his purchasing and providing such medical devices is a very subtle marketing tool. His patients are very appreciative of this gesture. A fellow jealous competing physician has reported this activity to the state medical board. The complaining physician

Chicago - With all the new at-home hair treatments and recent reports of contact dermatitis and other cutaneous manifestations from using shampoos, conditioners and hair dyes, dermatologists should be keenly aware of products that can harm patients' hair and skin.