Not only was there little to no correlation between drug resistanceand clinical response, but the rates of good responses were higherin the resistant patients than in those with non-resistant P. acnesfor four of the five antibiotics (75 percent to 100 percent vs. 65percent to 85 percent).
San Francisco - Interim results of a phase 2,vehicle-controlled, bilateral study evaluating the efficacy andsafety of broad area topical 5-aminolevulenic acid (ALA, LevulanKerastick, DUSA Pharmaceuticals) photodynamic therapy (PDT) withvarious light sources show that ALA plus blue light (BLU-U, DUSAPharmaceuticals) was significantly more effective than vehicle plusblue light in improving facial photodamage, but the statisticalanalyses did not find ALA pretreatment enhanced the benefitsachieved using an intense pulsed light source (IPL; Quantum,Lumenis) or a pulsed dye laser (PDL; VStar, Cynosure), said RobertA. Weiss, M.D., associate professor of dermatology, Johns HopkinsUniversity School of Medicine, Baltimore, and an investigator inthe phase 2 trial.
Future research will move in two directions: The timing and numberof electroporation treatments and experimentation with additionalgenes.
San Francisco - Faced with a jungle of potential conflicts ofinterest in their various roles as providers, educators, students,advisers, committee members and investigators, physicians mightconsider their answers to a few pragmatic questions in judging theethics of their conduct, according to David M. Pariser, M.D.,speaking at the 64th Annual Meeting of the American Academy ofDermatology (AAD), here.
What is your take on antibiotic resistance? How do you respond to statements that dermatologists have used antibiotics too indiscriminately, compounding resistance problems? Are we, as a specialty, doing something bad for medicine?
National report - While Internet use is expanding across theboard, dermatologists in private practice appear to rely moreheavily on the Internet than do their academic counterparts,according to a recent study.
The use of drugs and devices for conditions that are not otherwiseindicated is widespread among physicians and is generally notconsidered experimental or investigational.
Berlin -- According to a study reported in the March issue of the Archives of Dermatology, while three central injection sites are essential for the treatment of glabellar wrinkles with botulinum toxin A, the use of two additional injection sites targeting the frontalis muscle did not improve efficacy.
Padua , Italy -- Researchers at the University of Padua report that injections of a synthetic polymer may be helpful in treating some HIV patients' facial wasting associated with combination antiretroviral therapy.
Stanford, Calif. -- A Stanford University School of Medicine study has found that rheumatoid arthritis sufferers have a high risk of developing non-melanoma skin cancers, and that those being treated with TNF inhibitors together with methotrexate or prednisone are even more likely to develop skin cancer compared with osteoarthritis suffers.
Cleveland ? "What if there were no topical corticosteroids? Or if a patient were unable to use them?"
Atlanta -- "Community-acquired MRSA is just exploding among the urban patient population we serve," says Henry Michael Blumberg, M.D., an epidemiologist and director of the division of infectious disease at Emory University School of Medicine.
San Francisco ? The willingness of dermatologists to take a more active role in positions of influence and decision will ultimately determine whether the specialty and its reputation are safeguarded for the future, according to Clay J. Cockerell, M.D., speaking at the 64th Annual Meeting of the American Academy of Dermatology (AAD) in March.
National report ? While topical calcineurin inhibitors for treating atopic dermatitis (AD) continue to grab headlines, sources tell Dermatology Times that research into additional treatments for pediatric skin problems is progressing.
Q. What is Sepilift? Does it induce a skin tightening reaction as advertised?
National report ? Facelifts may give a person a renewed youthful appearance, but they can also have an unpleasant side effect ? the development of noticeable, large, blue veins. Temple veins, especially, tend to become more prominent after facelift procedures.
The key to effective, natural-looking hair transplantation is to study the natural patterns of the hair.
While the biggest successes in terms of research and efficacy have been seen with vitamin A, other vitamins also offer varying degrees of benefits, but documentation of such benefits in topical uses still leaves much to be desired.
In addition to efforts on the collagen front is another movement to develop peptides to mimic the activities of botulinium toxin in the neuro-muscular junction.
Scotts dale, Ariz. ? Fillers and botulinum toxin have become mainstays in cosmetic treatments in any state-of-the-art practice worldwide. Just how and when to employ these seemingly simple yet sometimes tricky-to-administer corrective injections can more often than not prove to be a challenging task for the inexperienced physician.
Study results demonstrated that the minimum concentration to inhibit the growth of 90 percent of bacteria tested (MIC 90) was lowest for retapamulin out of a total of 15 tested topical antibiotics.
Retired dermatologist and researcher Henry Earl Jones, M.D., has aninquisitive nature that led to a better understanding of theimmunology of fungal infection and an arsenal of badly needed drugsfor difficult-to-treat patients. His curiosity expands beyond themedical, however, and his questioning about why Californians werenot able to successfully grow Spanish grapes for wine led to hissecond career (after 35 years as a dermatologist), as owner of athriving U.S. winery.
Cleveland ? "What if there were no topical corticosteroids? Or if a patient were unable to use them?"
National report ? Modern goals for wart therapy are based on both lesion clearance and recurrence prevention, and achieving those objectives, especially in tough cases, usually requires a combination approach incorporating an agent that will provide antiviral and immunomodulatory activity, says Stephen K. Tyring, M.D., Ph.D.
According to Dr. Trowers, there is an increased efficacy of hydroquinone in higher concentrations in skin of color, especially when it is combined with chemical peels and/or tretinoin.
Treatment (e.g., with methotrexate) of systemic inflammatory diseases such as psoriasis and rheumatoid arthritis reduced the incidence of vascular diseases, presumably through its anti-inflammatory effect.
Miami ? Hemangiomas and vascular malformations are relatively common in children and sometimes prove difficult to manage.
San Francisco ? Dermatologists are seeing more community-acquired strains of methicillin-resistant Staphylococcus aureus (MRSA), according to John H. Epstein, M.D.
Geneva ? Interest in rapid diagnostics for methicillin-resistant Staphylococcus aureus (MRSA) is driven by the troubling increase in incidence and a growing understanding that hospital-acquired and community-acquired strains can have different patterns of resistance and susceptibility to drugs.
Atlanta -- "Community-acquired MRSA is just exploding among the urban patient population we serve," says Henry Michael Blumberg, M.D., an epidemiologist and director of the division of infectious disease at Emory University School of Medicine.
