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San Francisco ? While physician extenders represent one potential solution for underserved patient populations, they must only be used in supervised settings, according to an American Academy of Dermatology (AAD) official.

On a larger scale, he notes that few, if any, medical conferences could survive as currently structured without heavy subsidies from the pharmaceutical industry.

Sixty percent of families in which three or more members have melanoma also have a germline mutation in the p16 sequence, which, when functioning properly, inhibits CDK4 and activates RB1 (retinoblastoma). When the p16 function of human melanocytes is blocked, senescence is delayed.

It is a higher-viscosity hyaluronic acid manufactured by Q-Med, the same company that manufacturers Restylane for Medicis. Medicis purchased the marketing rights for Restylane in the United States and invested the time and money to get the filler approved. At some point, Medicis undoubtedly will obtain approval for Perlane and add this to its offerings.

The emphasis on blood vessel quantity over quality might explain why efforts to grow new vessels in patients with ischemic complications by simply supplying cells with VEGF have fared poorly.

Las Vegas ? Hormonal therapy with an estrogen-progestin oral contraceptive (OC) can be a useful adjunct for acne treatment in adult women who fail to respond to traditional topical and systemic therapies, according to Julie C. Harper, M.D., at the Fall Clinical Dermatology Conference.

As expected, based on experience using alefacept in patients with chronic plaque psoriasis, onset of response was somewhat slow. Over time, however, the treatment was associated with clinical improvement in most patients without any serious safety concerns.

In patients for whom rheumatologists once hoped to achieve 20 percent improvement, Dr. Lisse says that with TNF inhibitors, "We're now looking for 50 or 70 percent, or even remission."

The concept looks good from the outside: Offset the financial challenges of running a traditional dermatology practice by adding fee-for-service aesthetic procedures. However, dermatologists who have done it say that successfully launching or expanding a cosmetic practice requires more than whim. Dermatologists need to weigh the costs, realize the commitment they need to make to these patients and have the time to devote to an aesthetic practice.

Tucson, Ariz. ? In the months following a French surgical team'sgroundbreaking partial face transplant, details have emerged notonly about the recipient's identity and appearance, but also aboutthe precarious progress of the surgical outcome.

Barrington, Ill. -- The National Rosacea Society (NRS) announced last month that it has awarded research grants to five new studies aimed at advancing scientific knowledge of rosacea and finding new treatments to combat it.

Washington -- Amid a number of high-profile state and federal pharmaceutical liability cases, federal regulators are proposing to insert language in a prescription-drug rule that some state officials say would help drug companies defend themselves against lawsuits.

San Francisco — With the growing patient interest in cosmetic procedures and the ever-decreasing insurance reimbursements, there are always dermatologists considering expansion of their practices into the cosmetic field. Barry A.S. Lycka, M.D., of Edmonton, Alberta, Canada, has helped hundreds of doctors transition from clinically based practices to ones inclusive of cosmetic work. He plans to offer some basic tips on how to approach the change during the 64th Annual Meeting of the American Academy of Dermatology, taking place here March 3-7.

San Francisco — With the growing patient interest in cosmetic procedures and the ever-decreasing insurance reimbursements, there are always dermatologists considering expansion of their practices into the cosmetic field. Barry A.S. Lycka, M.D., of Edmonton, Alberta, Canada, has helped hundreds of doctors transition from clinically based practices to ones inclusive of cosmetic work. He plans to offer some basic tips on how to approach the change during the 64th Annual Meeting of the American Academy of Dermatology, taking place here March 3-7.

Transportation

The airport is located 14 miles south of downtown San Francisco, in San Mateo County. For public transit information to the airport, contact BART, SamTrans or Caltrain. Muni does not serve the San Francisco International Airport (SFO).

Walking Tours

If you're a first-time visitor, hop the Powell-Hyde cable car downtown. It will carry you to Victorian Park, and downhill to the north is Hyde Street Pier with many early California coastal vessels. All four museum ships are open to the public. From the Pier, turn right (west) along the Aquatic Park shoreline. A cement path leads past a patch of Italy (the bocce ball courts) onto the crescent-shaped Municipal Pier. Returning via Beach Street, stop in at the ship-shaped National Maritime Museum at the foot of Polk Street. Across the street is Ghirardelli Square, which was once a woolen mill, later a chocolate factory and now a popular retail/dining complex.

Shopping

San Francisco's souvenir superstore, located at Pier 39, is one of the largest retailers of San Francisco gifts, souvenirs and apparel. Open daily, 8 a.m. to 10 p.m. Pier 39 (415) 397-0143 www.onlyinsanfrancisco.net

Convention Cuisine

For lunch close to the Moscone Center, try some of these favorites.