An experimental vaccine being studied in patients with stage IIB and IIC melanoma is demonstrating positive outcomes in recurrence-free survival and a favorable adverse event profile, one expert says.
The experimental vaccine offers hope to a patient population in need of more effective therapies with far fewer and more tolerable adverse events, particularly when compared with currently available therapies for this patient population, says Craig L. Slinglu Jr., M.D., professor of surgery, director of the human immune therapy center and co-leader of the cancer therapeutics program, UVA Cancer Center, Charlottesville, Va.
“Interferon is the only treatment that is currently approved for stage IIB and IIC melanoma after surgery,” he says. “Because of its associated toxicity and the variability in the benefit seen in different trials; however, a need for better treatment options perhaps in the form of a vaccine could prove very useful in this subgroup of patients.”
The MAVIS (Melanoma Antigen Vaccine Immunotherapy Study) clinical trial is an ongoing multicenter, double-blind, placebo-controlled, phase 3 clinical study investigating seviprotimut-L (Polynoma LLC), an experimental allogenic, polyvalent, partially purified shed melanoma antigen vaccine derived from three proprietary human melanoma cell lines. It is designed to stimulate the patient’s humoral and cellular immune responses.
Researchers are examining the safety and efficacy of the vaccine with primary endpoints of RFS and overall survival (OS) in patients with American Joint Committee on Cancer (AJCC) stage IIB/C, IIIA, IIIB/C melanoma at high risk of recurrence after definitive surgical resection.
Dr. Slinglug reports no relevant disclosures.