National report — Preliminary review finds no adverse effects of anti-TNF-alpha agents on pregnancy outcomes. Analyses of limited data collected by the Organization of Teratology Information Services (OTIS) suggest there is no increased risk of major malformations or spontaneous abortions in women who received treatment with an anti-TNF-alpha medication early during pregnancy, reports Christina Chambers, Ph.D., M.P.H., who is current President of OTIS, assistant professor, departments of pediatrics and family and preventive medicine, University of California San Diego, La Jolla, Calif.