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New York - A combination regimen beginning with adapalene cream 0.1 percent (Differin, Galderma) and incorporating the fixed triple-combination depigmenting cream (Tri-Luma Cream, Galderma) provides a well-tolerated and effective method for treating acne and its distressing sequel of post-in-flammatory hyperpigmentation (PIH) in African-American patients, said Valerie D. Callender, M.D., at the recently held Academy '04 meeting of the American Academy of Dermatology.

Cosmetic Conundrums

How much does a patient need to pay for an effective facial moisturizer?

Winston-Salem, N.C. - Pigmented lesions come in many forms, and while many do not require treatment, they sometimes serve as signs of seriousconditions, says Zoe D. Draelos, M.D.

A large video clip can be difficult to send over the Internet, and can be difficult for viewers to download... Reducing the frame rate to one-third of the original led to a great reduction in file size, and it reduced the rate at which data had to be sent.

New York - While dermatologists need to be aware of legitimate safety issues when prescribing any of the TNF-? antagonists for the treatment of psoriasis, as a bottom line, adalimumab (Humira, Abbott Immunology), etanercept (Enbrel, Amgen/Wyeth), and infliximab (Remicade, Centocor) appear to be safer than some older psoriasis treatments, such as methotrexate and cyclosporine, says Mark Lebwohl, M.D., Sol and Clara Kest Professor and chairman, department of dermatology, Mount Sinai School of Medicine, New York.

New York - While acitretin remains a common oral treatment for psoriasis, oral tazarotene (Allergan), fumaric acid esters (FAEs), and oral pimecrolimus can cut side effects ranging from alopecia to liver and kidney damage, according to a recent study.

Research shows that less than half of patients with severe psoriasis in the United States receive aggressive treatment - systemic drugs, biologic drugs or phototherapy - for their disease. The total number of severely psoriatic patients has been estimated at 120,000 to 450,000 or more.

New York - Results of a retrospective review reinforce the long-term safety and tolerability of repeated treatments with botulinum toxin type A (Botox Cosmetic?, Allergan) for cosmetic reasons, said Alastair Carruthers, M.D., at the American Academy of Dermatology's Academy '04 here recently.

New Orleans - BAY 43-9006, a novel signal transduction inhibitor, has very modest activity as a single agent in melanoma; however, it has promising activity in combination with chemotherapy, investigators said at the annual meeting of the American Society of Clinical Oncology (ASCO).

Controversial as they are, the new regulations have focused attention on the complex payroll withholding system that every dermatology practice must deal with.

You're fired

Firing a patient or terminating the physician-patient relationship (PPR)... requires following a certain protocol in order to be accomplished successfully, without risk of litigation from the patient and/or the family.

International report - Some soldiers serving in Iraq say military policies that restrict the wearing of hats during physical training are leaving them unprotected from potentially deadly sun exposure.

New York - Melanoma-derived peptide vaccines are currently an exciting area of melanoma immuno-therapy research, according to Douglas J. Schwartzentruber, M.D., medical director and director of the Center for Cancer Care at Goshen Health System, Goshen, Ind., speaking at the Society of Surgical Oncology annual meeting.