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Mario E. LaCouture, M.D., discovered during his residency that the role of dermatology in cancer patients' lives was much greater than just treating skin cancers. He would watch as breast, lung, colon and other cancer patients would complain about the damage that anticancer treatments - especially the new biologics - were doing to their skin. Patients in phase 1 and 2 clinical trials, who had exhausted their treatment options, were having to forgo life-prolonging treatment because of life-altering cutaneous effects, including itching so severe that they could not function or sleep.

Over the last decade, an increasing number of doctors have looked at international approaches to their wealth planning. There are numerous pitfalls for using international planning that can catch naïve doctors. Learn what to do - and what to avoid - in international planning, and about specific tools top attorneys use in their international planning.

As I write this, millions of Americans are straining under the pressures of a fickle, unpredictable economy. Tens of thousands of workers have lost their jobs in recent months, savers are struggling to make sense of the lowest interest rates that some have ever seen, and the stock market has given new meaning to the word "volatility." All of this while gasoline and food prices surge to record highs.

Emerging data indicate the sentinel lymph node biopsy may not only stage the regional lymph nodes of patients with melanoma and have prognostic value, but may be therapeutic as well. Data from the Multicenter Selective Lymphadenectomy Trial (MSLT-1), an investigation consisting of patients with clinically node-negative melanoma, demonstrated a survival advantage in a subset of patients who had a positive node.

The efficacy and safety of a cosmeceutical cream containing conjugated linoleic acid (CLA) for improving the appearance of facial photodamage skin was investigated in a 16-week, randomized, double-blind, split-face study of 25 women. Assessments of changes in periorbital skin showed statistically significant differences favoring use of the CLA-containing cream. No skin irritation was noted throughout the study.

With the continued introduction of laser devices with unique delivery systems and wavelengths, the issue of eye safety is becoming increasingly complicated. Consistent and competent eye safety procedures for operator, patient, observer and assistant are crucial to a safe and successful laser practice. Despite our increased knowledge of lasers and laser safety, eye injuries in the workplace are still a common problem, with many injuries going undetected well after the incident.

Two identical pivotal trials evaluating the safety and efficacy of autologous fibroblast therapy (Isolagen Technologies) compared with placebo are almost finished. Special attention was paid in protocol design so there would be consistency across the studies in cell harvesting and injection technique, as well as in outcomes assessments. The treatment protocol, which varies from previous studies, aims to optimize the treatment effect.

A study showing that the periocular area and skin color uniformity are key drivers of perceived age suggests that aesthetic physicians and skincare companies should target these attributes, authors say.

Although Asians are the fastest-growing population group in the United States, most dermatologists are not familiar with differences in the skin of Asians as compared to Caucasian patients. Signs of aging are different, and more delicate treatment is needed for sensitive Asian skin.

Fungal isolates from patients with tinea capitis participating in international clinical trials were tested for in vitro susceptibility to terbinafine. The results showed terbinafine had potent activity against all 301 dermatophytes tested. There was no difference in MIC values comparing U.S. and non-U.S. isolates of the same organism.