The Aesthetic Edge: October 2025

Stay up-to-date with the latest research and trends in aesthetics to keep patients informed in the October edition of The Aesthetic Edge. Dermatology Times asks our readers to share the latest aesthetic formulas and innovative technologies they’ve been seeing in the clinic. Is there a new skin care product that you’ve recommended to your patients or have conducted research on? Email DT's Assistant Editor, Marie Bosslett (mbosslett@mjhlifesciences.com) to share your insights and experience with our audience of clinicians, and you may be featured in an upcoming roundup!

Peptide Facial Refining Concentrate | ZO Skin Health

This wrinkle-modulating and plumping serum targets visible expression and static wrinkles, while restoring the appearance of lost volume for smoother, fuller-looking skin. Powered by 4 unique peptide technologies and ZO's ZPOLY Complex, the formula reaches areas where neurotoxins can’t be used while soothing redness and supporting the skin’s barrier. In a 12-week independent, third-party clinical study consisting of 49 female patients aged 47 to 72, 92% of participants saw a reduction in the appearance of fine lines, 84% said they had a visibly younger-looking facial geometry, and 86% saw visible improvement in facial hollow areas.¹ The concentrate is suitable for all skin types and is especially recommended for patients looking to improve signs of aging, either with this standalone treatment or as a complement to dermal filler and other injectable procedures. It’s also great for those experiencing loss of contour due to rapid weight loss. Clinicians can register to become a ZO provider and purchase the product here.

“This formula represents a major leap forward in at-home peptide technology. By supporting skin health and complementing the appearance of neurotoxin and filler results, Peptide Facial Refining Concentrate bridges the gap between the office and the bathroom counter.” - Tina Pai, MD, board-certified dermatologist at Skin Spectrum in Tucson, Arizona, told Dermatology Times.

AlphaRet Body Overnight Cream | skinbetter science

skinbetter science’s AlphaRet technology is the foundation of this body lotion, designed for areas with thicker, rougher skin, especially on the arms, elbows, and hands. AlphaRet combines a retinoid with lactic acid, delivering visible improvements in fine lines, texture, and tone with minimal irritation compared to traditional retinoids.² Because AlphaRet is more tolerable than other products on the market, patients can maintain consistent use, leading to faster and more noticeable results. Over 87% of patients who used the overnight cream in a 12-week trial saw visibly firmer, smoother skin, even on those with sensitive skin. With gentle yet effective exfoliating and hydrating properties, this product enables patients to maintain improvements in skin texture, firmness, and overall appearance all year round.

“AlphaRet is unique because it combines a retinoid with lactic acid, an alpha hydroxy acid (AHA) that is naturally found in the skin and also hydrates by attracting moisture. Traditional retinoids can be effective but often cause irritation; AlphaRet provides exfoliation and renewal in a gentler, more balanced way.” - Deanne Mraz Robinson, MD, FAAD, co-founder of Modern Dermatology and DMR Research in Westport, Connecticut, assistant clinical professor of dermatology at Yale University of Medicine, and Dermatology Times Editorial Advisory Board member, said.

The Pimple Patches | JB SKRUB

Inspired by their experience as “boy moms,” Julie Bowen and Jill Biren teamed up with expert dermatologists to create JB SKRUB, a skin care brand designed with teenagers in mind. With bright packaging and simplified ingredient lineups that stand out in an oversaturated market, the company makes prioritizing skin health quick, easy, and safe for young patients. Their latest launch of pimple patches was highly requested by their customers and synergistically combines hydrocolloid, salicylic acid, and niacinamide to shrink breakouts in as little as 6 to 8 hours. While most hydrocolloid patches offer a one-size solution, these come in multiple sizes to treat, soothe, and protect inflamed and clogged skin in a unique, multi-ingredient approach. Stability tested for 6 months and formulated to meet EU standards, the clear patches are perfect for all patients with mild to moderate/hormonal acne, not just adolescents.³

"I recommend JB SKRUB pimple patches to my preteen and teen patients as a quick-acting, on-the-spot treatment for pimples that pop up. Not only do they help prevent picking, which can lead to scarring, but they actually treat the pimple, helping to unclog, dry up and reduce inflammation." - TsipporaShainhouse, MD, board-certified pediatrician and dermatologist at SkinSafe Dermatology and Skin Care in Beverly Hills, California, said to Dermatology Times.

Glo2Facial | Geneo

The Glo2Facial in-office device uses proprietary Oxfoliation and RF Pro (radiofrequency) technologies along with ultrasound and detox massage to drive skin regeneration from within. Its synergistic multi-modality approach stimulates oxygenation, boosts circulation, enhances product absorption, and activates collagen remodeling with no downtime. Patients see, on average, a 23% increase in oxygen levels, a 19% decrease in perioral wrinkle volume, and a 41% decrease in periorbital wrinkle volume, promoting visible anti-aging benefits and accelerating the skin’s natural regenerative process.⁴ With 7 customizations to target all major skin concerns, this comfortable treatment is suitable for all skin types and ages, including those with hyperpigmentation, skin laxity, and acne. In fact, over 77% of participants reported noticeable improvement in overall skin texture. The device is also great for prep and post-care for more invasive procedures such as injections and lasers.

“I think Glo2Facial is a great thing for the older patient, because it's a great adjunct, but I think it's a tool that we didn't have before to get the younger population started...anybody who has skin is a great candidate.” - Amy B. Lewis, MD, cosmetic dermatologist at Lewis Dermatology & Associates in New York City, said in an interview with Dermatology Times.

Sunlight Drops with Drop Finder Technology | Pour Moi Skincare

Adding to the line of “Climate-Smart” products, this glowy serum booster delivers a vitamin-D-like stimulus to the epidermis without UV exposure, perfect for when skin lacks sunlight during the winter months or for patients who spend extended hours indoors. Bolstered by Climate-Smart Shield and MossCellTec technology, the drops aim to maintain skin’s hydration, resilience, and barrier repair. The hero ingredient here is 2% Cichorium intybus root extract, which clinically improved skin barrier function, reduced transepidermal water loss, and reactivated vitamin D receptors by over 32% in a randomized, double-blind study.⁵ It’s a great adjunct to daily sunscreen use and can easily be incorporated into patients’ existing routines by being applied on its own or mixed into moisturizer, body lotion, and makeup.

“In patients who aren’t getting much sun—whether during winter months, indoor lifestyles, or with diligent daily SPF—we often see barrier issues and dullness increase. Sunlight Drops provides a way to activate vitamin D-like signaling directly in the epidermis without UV exposure. Clinical studies on the chicory-root active show increased vitamin D receptor activity, improved differentiation, and faster barrier recovery. That’s why I recommend it as a daily booster under sunscreen to help maintain skin resilience.”- Iffie Okoronkwo, MD, Scientific Advisor of Pour Moi, said in a statement to Dermatology Times.

References

1. ZO® Skin Health Launches Peptide Facial Refining Concentrate to Complement In-Office Procedures. Available Exclusively through Authorized ZO® Providers. News release. PR Newswire. Published September 16, 2025. Accessed October 15, 2025. https://www.prnewswire.com/news-releases/zo-skin-health-launches-peptide-facial-refining-concentrate-to-complement-in-office-procedures-available-exclusively-through-authorized-zo-providers-302558051.html

2. McDaniel DH, Mazur C, Wortzman MS, Nelson DB. Efficacy and tolerability of a double-conjugated retinoid cream vs 1.0% retinol cream or 0.025% tretinoin cream in subjects with mild to severe photoaging. J Cosmet Dermatol. 2017;16(4):542-548. doi:10.1111/jocd.12381

3. Meet the JB SKRUB Team Who Want Cleaner Kids. JB SKRUB Advisory Board. https://jbskrub.com/pages/advisory-board

4. Levenberg A. Clinical experience with a TriPollar radiofrequency system for facial and body aesthetic treatments. Eur J Dermatol. 2010;20(5):615-619. doi:10.1684/ejd.2010.1042

5. Maia Campos PM, G Mercurio D, O Melo M, Closs-Gonthier B. Cichorium intybus root extract: A "vitamin D-like" active ingredient to improve skin barrier function. J Dermatolog Treat. 2017;28(1):78-81. doi:10.1080/09546634.2016.1178695