Abnormalities in epidermal barrier integrity, affecting factors such as epidermal calcium gradients, filaggrin, cornified envelopes, desquamation of corneodesmosomes and skin lipids, may also influence epidermal barrier dysfunction, according to a review that examined molecular mechanisms of epidermal barrier dysfunction as primary abnormalities published February 11 in the International Journal of Molecular Sciences.
Epidermal barrier dysfunction can cause eczema and other skin disorders. Eczema is among the skin conditions that can also damage the epidermal barrier, in what often is a vicious cycle further complicated by immunologic responses and other mechanisms.
Researchers are increasingly studying molecular mechanisms involved in epidermal barrier dysfunction, attempting to identify the causative molecules.
“The data identified in skin disorders caused by monogenic defects related to epidermal barrier dysfunction could provide reliable clues or insight into the mechanisms concerning epidermal barrier dysfunction as primary events,” the authors write.
The authors studied categories of epidermal barrier abnormalities, looking at molecular mechanisms linked to ichthyoses, eczema, or atopic dermatitis, without exacerbation or lesion and early time of experimental irritation.
No conflicts of interest reported.
Lee AY. Molecular Mechanism of Epidermal Barrier Dysfunction as Primary Abnormalities. Int J Mol Sci. 2020;21(4)