Opinion|Videos|March 21, 2025

The Role of IL-17 in Psoriasis Pathogenesis

Panelists discuss how IL-17 is a key pro-inflammatory cytokine in plaque psoriasis pathogenesis. It stimulates keratinocyte proliferation, promotes neutrophil recruitment, induces antimicrobial peptides, and up-regulates other inflammatory mediators, creating a self-perpetuating inflammatory cascade in lesional skin.

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Video content above is prompted by the following:

  • What is the role of IL-17 in the pathogenesis of plaque psoriasis, and how does it contribute to inflammation?

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