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Opinion|Videos|April 11, 2025

Long-Term Efficacy and Safety of IL-17 Inhibitors in Psoriasis

Panelists discuss how long-term data confirm the sustained efficacy and safety of IL-17 inhibitors in psoriasis. Secukinumab (Bissonnette, 2018; Langley, 2022) and ixekizumab (Blauvelt, 2021) show durable PASI responses over 5 years. Brodalumab’s 5-year pharmacovigilance (Lebwohl, 2024) and 120-week data (Puig, 2020) support its long-term use. Bimekizumab’s 4-year data (Blauvelt, 2024; Gordon, 2024) demonstrate continued efficacy, with 5-year results anticipated at AAD 2025.

Episodes in this series

Video content above is prompted by the following:

  • What do we know about the long-term safety and efficacy of IL-17 inhibitors in psoriasis?
    • Secukinumab 5-year data (Bissonnette, 2018; Langley, 2022)
    • Ixekizumab 5-year data (Blauvelt, 2021)
    • Brodalumab 5-year pharmacovigilance (Lebwohl, 2024); 120-week data (Puig, 2020)
    • Bimekizumab 4-year data (Blauvelt, 2024; Gordon, 2024); 5-year data expected at AAD 2025

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