
Opinion|Videos|October 7, 2024
Examining Molecular Differences in PDE4 Inhibitors in Pediatric Patients with Plaque Psoriasis
Author(s)Karan Lal, DO, MS, FAAD, Helen T Shin, MD
Key Takeaways
- Roflumilast is used for COPD, reducing exacerbations but may cause gastrointestinal side effects.
- Apremilast is indicated for psoriatic arthritis and plaque psoriasis, with a favorable safety profile.
Panelists discuss how the two approved PDE4 inhibitors for pediatric plaque psoriasis differ in their systemic treatments, highlighting key differences in efficacy, safety profiles, and patient considerations for optimal use.
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Episodes in this series

Video content above is prompted by the following:
- Currently there are two approved PDE4 inhibitors in this category. Could you provide an overview of these systemic treatments, highlighting their key differences and considerations in terms of efficacy and safety?
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