10 Frequently Asked Questions About Generalized Pustular Psoriasis

Generalized pustular psoriasis (GPP) can move from first pustule to multiorgan failure in hours, yet the disease remains widely underrecognized outside specialty dermatology, and misdiagnosis in the emergency setting is common.^1,2 A National Psoriasis Foundation consensus statement and a Canadian emergency medicine "Just the Facts" review each lay out what separates GPP from its mimics, why biopsy is not the diagnostic gatekeeper many assume it to be, and how the arrival of IL-36 pathway inhibition has reshaped acute and maintenance management.^1,2 The 10 questions below translate both sources into a practical reference for identifying GPP early and managing it correctly.