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Maddi Hebebrand is an associate editor of 

and joined the MJH Life Sciences team in May 2024. She attended Baldwin Wallace University, studying Media Production and Film, and received her Masters in Digital Media from Ohio University. When she's not writing, Maddi loves to read, attend concerts and spend time with her family. 

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Continuity with a known physician and rapid response times significantly increased patient willingness to use teledermatology. 

Teledermatology Preferences Among Patients with Psoriasis 

and joined the MJH Life Sciences team in February 2023. She attended Kent State University and earned a Bachelor of Science degree in journalism with minors in public relations and creative writing. She enjoys making and listening to music, reading, and spending time with her cats, Astrid and Marceline.

Palvella has secured its 5th US patent for Qtorin rapamycin, extending intellectual property coverage to 2038 and advancing treatment for microcystic lymphatic malformations.

Palvella Secures New US Patent for Qtorin Rapamycin in Microcystic Lymphatic Malformations

A survey by LEO Pharma indicates widespread misunderstandings about chronic hand eczema, revealing significant emotional and occupational challenges for patients.

Survey Unveils Impact of Chronic Hand Eczema on Patients’ Lives and Treatment Landscape

Catch up on dermatology news, highlights, and insights from the past 24 hours.

Daily Derm Times: April 21, 2025

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Final Thoughts: The Importance of Comparative Studies in AD

Panelists offer concluding insights and emphasize the critical role of comparative studies in advancing atopic dermatitis treatment strategies.

clinical

Video Series

 (Dupixent; Regeneron and Sanofi) for the treatment of chronic spontaneous urticaria (CSU) in patients aged 12 years and older who have not previously reached controlled disease status with H1 antihistamine treatment.

The approval marks the introduction of the first targeted therapy for CSU in more than a decade.

“[Dupilumab] is the first new targeted treatment for chronic spontaneous urticaria, or CSU, in over 10 years, with pivotal trials demonstrating its ability to help patients significantly reduce the hallmark symptoms of intense itch and unpredictable hives associated with this disease," said George D. Yancopoulus, MD, PhD,  board co-chair, president, and chief scientific officer at Regeneron. "With this FDA decision, [dupilumab] is now approved for 7 chronic, debilitating atopic conditions driven in part by underlying type 2 inflammation, several of which have been shown to co-morbidly occur with CSU, such as atopic dermatitis and asthma – providing patients with one treatment that might help multiple atopy conditions. We look forward to bringing [dupilumab] to the more than 300,000 CSU patients in the US with inadequately controlled disease on standard-of-care treatment who, until now, had limited treatment options.”

Dupilumab, an interleukin-4 (IL-4) and interleukin-13 (IL-13) inhibitor, has already been approved for multiple type 2 inflammatory conditions, including atopic dermatitis, asthma, eosinophilic esophagitis, and prurigo nodularis.

The approval comes after years of research and regulatory engagement. In October 2023, the 

 for the initial supplemental Biologics License Application (sBLA),

 stating that additional efficacy data were needed to support approval. However, the agency did not identify concerns regarding dupilumab’s safety or manufacturing process.

In response to the CRL, Regeneron and Sanofi resubmitted the sBLA, which was 

 That resubmission included updated efficacy and safety data from a third phase 3 trial, LIBERTY-CUPID Study C, in biologic-naïve patients with CSU uncontrolled by antihistamines.

LIBERTY-CUPID: Building the Case for Approval

The LIBERTY-CUPID (NCT04180488) clinical development program, which supported the approval, consisted of 3 randomized, double-blind, placebo-controlled phase 3 trials.

: Conducted in biologic-naïve CSU patients whose symptoms remained uncontrolled despite H1 antihistamine therapy.

: Conducted in patients who were not only uncontrolled on H1 antihistamines but also refractory or intolerant to omalizumab (Xolair; Novartis).

Across the trials, patients receiving dupilumab experienced significant improvements in CSU symptoms. In Study C, which provided the pivotal data for approval, nearly half of participants achieved well-controlled disease status, marked by meaningful reductions in itch severity and hives, compared with placebo. These findings aligned with earlier results seen in Study A, reinforcing the drug’s efficacy.

Adverse events observed during the studies were consistent with dupilumab’s known safety profile. The most common adverse effects included injection site reactions and COVID-19 infections, which occurred in both treatment and placebo groups. No new safety signals were identified.

Filling a Decade-Long Gap in CSU Treatment

Prior to today’s approval, patients with CSU who did not respond to H1 antihistamines had limited treatment options, most notably omalizumab, an anti-IgE monoclonal antibody.

Dupilumab’s approval fills this gap as the first new targeted therapy for CSU in more than 10 years, and the only approved biologic that inhibits IL-4 and IL-13 signaling, key drivers of type 2 inflammation.

"It’s been 10 years with no innovation for chronic urticaria… now to switch gears for a new approval that the dermatology specialists are familiar with… ultimately, the patients benefit," said Jason Hawkes, MD, MS, a board-certified dermatologist and co-owner, chief scientific officer, and investigator at the Oregon Medical Research Center in Portland, Oregon, in a 

"Most of these patients—around 50%—don’t respond to antihistamines, even at high-doses," Hawkes added.

The companies are expected to launch Dupixent for CSU in the near future.

"It's going to bring patients into a specialty dermatology that hasn't really been managing these patients. We're going to pick up new observations, new insights," Hawkes said. "Dermatology specialists are familiar and comfortable with this therapy. They use it for other indications, but now they have a familiar therapy for a disease that they know how to recognize but weren't historically treating. I think [dupilumab] comes into that landscape where they
have the comfort with the therapy that's had a very good safety record having, in some indications, approval down to even 6 months of age."

Dupixent® (dupilumab) approved in the US as the first new targeted therapy in over a decade for chronic spontaneous urticaria (CSU). News release. Globe Newswire. April 18, 2025. Accessed April 18, 2025. 

https://www.globenewswire.com/news-release/2025/04/18/3064133/0/en/Dupixent-dupilumab-Approved-in-the-U-S-as-the-First-New-Targeted-Therapy-in-Over-a-Decade-for-Chronic-Spontaneous-Urticaria-CSU.html

Regeneron and Sanofi provide update on Dupixent (dupilumab) SBLA for chronic spontaneous urticaria. News release. Regeneron Pharmaceuticals Inc. October 20, 2023. Accessed April 18, 2025. 

https://investor.regeneron.com/news-releases/news-release-details/regeneron-and-sanofi-provide-update-dupixentr-dupilumab-sbla

Dupixent (dupilumab) sBLA accepted for FDA review for the treatment of chronic spontaneous urticaria (CSU). News release. Regeneron. November 15, 2024. Accessed April 18, 2025. 

https://investor.regeneron.com/news-releases/news-release-details/dupixentr-dupilumab-sbla-accepted-fda-review-treatment-chronic

Dupilumab for the treatment of chronic spontaneous urticaria in patients who remain symptomatic despite the use of H1 antihistamine and who are naïve to, intolerant of, or incomplete responders to omalizumab (LIBERTY-CSU CUPID). ClinicalTrials.gov ID NCT04180488. Last updated December 11, 2024. Accessed April 18, 2025. 

https://clinicaltrials.gov/ct2/show/NCT04180488

Dupilumab becomes the first targeted therapy approved for chronic spontaneous urticaria in more than a decade.

FDA Approves Dupilumab for Adolescents and Adults With H1 Antihistamine-Refractory Chronic Spontaneous Urticaria

Cabtreo (Ortho Dermatologics; formerly known as IDP-126) was approved by the US Food and Drug Administration

 (FDA) in October 2023 for the treatment of patients aged 12 years and older with acne vulgaris. Cabtreo is the first FDA-approved fixed-dose triple-combination gel (clindamycin 1.2%/adapalene 0.15%/benzoyl peroxide 3.1%) for patients with acne. Cabtreo is expected to be available in Q1 of 2024.

, more than half (52.5%) of patients treated with Cabtreo achieved treatment success as measured by a 2-point or greater reduction from baseline in Evaluator’s Global Severity Score and clear or almost clear skin. In the first of the phase 3 trials, the proportion of patients treated with Cabtreo achieving clear or almost clear skin (49.6%) was significantly greater than patients being treated with a vehicle gel (24.9%). The second phase 3 trial demonstrated consistent significant rates of treatment success among Cabtreo- treated patients (50.5%) versus patients in the vehicle gel group (20.5%).

What are your thoughts about Cabtreo as the newest acne topical? Email us at 

Cabtreo, a fixed-dose triple-combination gel, received FDA approval in October 2023 for treating acne vulgaris in patients aged 12 and older. It combines clindamycin, adapalene, and benzoyl peroxide, marking the first such approved formulation. Clinical trials demonstrated its efficacy, with over half of the patients achieving significant improvement in acne severity. Phase 3 trials showed Cabtreo's superiority over a vehicle gel, with nearly 50% of patients achieving clear or almost clear skin. Cabtreo is anticipated to be available in the first quarter of 2024.

Click here to answer this week's acne poll.

Polls 

POLL: Have Your Patients Asked About Cabtreo for Acne?

Last week, our Hyperhidrosis Awareness Month poll

 challenged your knowledge of the prevalence of excessive sweating. We asked: What percent of the global population is estimated to have hyperhidrosis? 

, according to the International Hyperhidrosis Society. Despite how common hyperhidrosis is, it is estimated that 27% of those with the condition never receive a diagnosis.

Even more so, not everyone who experiences excessive sweating has shared their symptoms and experiences with a health care professional.

 wants to hear from you. What percent of those with hyperhidrosis have discussed their excessive sweating with a health care professional?

 to share your hyperhidrosis insights or research.

Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. 

. 2016;308(10):743-749. doi:10.1007/s00403-016-1697-9

Click here to answer this week's poll for Hyperhidrosis Awareness Month.

POLL: What Percent of Those With Hyperhidrosis Have Discussed Their Sweating With a Health Care Professional?

Revolutionizing Atopic Dermatitis (RAD) Annual Meeting

 has unveiled its comprehensive agenda for the upcoming 7th annual conference, scheduled for June 6-7, 2025, in Nashville, Tennessee. This year's event promises an engaging lineup of sessions and esteemed speakers, continuing to advance knowledge and fostering innovation in the field of atopic dermatitis (AD).​

 to view the full agenda and learn more about registration and attendance.

The 2-day conference is structured to cover a wide array of topics pertinent to AD, featuring sessions led by numerous experts in dermatology. Below is an overview of the scheduled sessions:​

Pediatric AD: Patient, Provider, Caregiver Connection

Assessing the Evidence for OX40-OX40L Axis Inhibition for the Treatment of Atopic Dermatitis

The meeting will also feature late-breaking research presents and poster/abstract submissions.​

The RAD 2025 conference boasts a distinguished roster of speakers, each bringing a wealth of expertise and insight into various facets of AD:​

Bunick will explore the emerging role of OX40-OX40L axis inhibition in AD treatment, analyzing the latest evidence and its potential impact on patient care. His session will provide key insights into this novel therapeutic approach.

: Leading the session on the psychosocial burden of AD, Shahriari will explore the emotional and psychological challenges faced by patients, emphasizing the importance of holistic care approaches.​

: Chovatiya will delve into the role of Janus kinase inhibitors in AD treatment and discuss the strategic use of topicals and biologics, providing attendees with a comprehensive understanding of current therapeutic options.​

: Addressing complex cases involving AD and hair loss, Mayo will shed light on the intersection of these conditions and offer guidance on effective management strategies.​

: With sessions focusing on recent approvals in AD therapy and managing itch, Silverberg will provide updates on the latest treatment advancements and strategies for alleviating pruritus.

: Lio will lead discussions on the unique challenges of treating pediatric AD, emphasizing the importance of patient-provider-caregiver collaboration. His session will address both clinical strategies and the psychosocial aspects of managing AD in younger populations.

: As an expert on chronic hand eczema, Yu will highlight the challenges associated with this condition in the context of AD, providing best practices for diagnosis and treatment.

 is proud to have been a long-standing partner of RAD, providing in-depth 

coverage of its 2024, 2023, and 2022 in-person and virtual events

’ parent company—in November 2024, RAD is now part of our family of educational resources.

As RAD enters its next chapter under the 

 looks forward to continuing the tradition of delivering exclusive coverage of the meeting’s groundbreaking sessions and expert discussions. Leading up to this year's event, we will be previewing key sessions with insights from featured speakers, and our team will be on-site in Music City to bring real-time coverage, expert pearls, and updates on the most important innovations in AD.

Stay tuned for updates as more speakers and late-breaking research presentations are announced. For registration details and additional information, visit the official 

Use code DT40 for 40% off your RAD 2025 registration.

MJH Life Sciences acquires Revolutionizing Atopic Dermatitis (RAD) Annual Meeting; expands leadership in dermatology education. News release. Accessed April 2, 2025. 

https://www.globenewswire.com/news-release/2024/11/18/2982960/0/en/MJH-Life-Sciences-acquires-Revolutionizing-Atopic-Dermatitis-RAD-Annual-Meeting-expands-leadership-in-dermatology-education.html

The 7th annual Revolutionizing Atopic Dermatitis (RAD) meeting, set for June 6-7, 2025, in Nashville, will feature a diverse agenda focusing on advancements in atopic dermatitis (AD). Esteemed speakers will cover topics such as JAK inhibitors, psychosocial impacts, pediatric AD, and chronic hand eczema. The conference will also present late-breaking research and poster submissions. Dermatology Times, now part of MJH Life Sciences, will provide comprehensive coverage of the event, highlighting key sessions and innovations in AD treatment and management.

Get a glimpse of the cutting-edge atopic dermatitis research, breakthroughs, and insights to be presented at the 7th RAD Annual Meeting, June 6-7, 2025.

Exploring the 2025 Revolutionizing Atopic Dermatitis (RAD) Annual Meeting Agenda

In the second round of breakout sessions at the 

 in Las Vegas, Nevada, Omar Noor, MD, FAAD; Douglas DiRuggiero, DMSc, MHS, PA-C; and Lakshi Aldredge, MSN, ANP-BC, DCNP, FAANP, focused on common challenges and innovations in treating plaque psoriasis and atopic dermatitis (AD). To foster collaboration and discussion around the cases, the meeting attendees were divided into 3 groups, with each Horizons chair moderating a session. 

 of a woman aged 27 years who had eczematous lesions covering more than 20% of her body surface area. N

 of a woman aged 25 years who presented with erythematous and scaly patches on her face, neck, and upper trunk.

Aldredge led the third breakout group, which tackled issues in AD in pediatrics and topical treatment options. She shared the case of a female patient aged 12 years with moderate AD that had been worsening over the past several months. The patient presented with 8% BSA; areas impacted included the hands, arms, and trunk. The patient reported persistent itching, redness, and discomfort, particularly on her hands. Like the previous patients, she reported sleeping difficulties stemming from the itch.

The history revealed the patient had onset of symptoms when she was 10, Aldredge reported. There is a familial history of asthma (her father) as well as a history of hay fever (her mother). Past treatments included a short history of oral antihistamines during severe itching episodes. She also received crisaborole 2%.

The patient is using daily emollient and moisturizer as well as a topical corticosteroid (mometasone 0.1%). The patient’s parents report they have been reluctant to try topical therapies on the hands. Moreover, they are concerned about the long-term use of corticosteroids, especially the thinning of skin. Both the patient and the parents are looking for fast-acting, effective treatment, Aldredge told attendees.

Aldredge reviewed the treatment landscape of topical therapies for AD, including prescription moisturizers, topical corticosteroids, topical calcineurin inhibitors, topical PDE4 inhibitors, topical JAK inhibitors, and topical antimicrobials. In doing so, she noted the GRADE (Grading of Recommendations Assessment, Development and Evaluation), strength of recommendation, and the severity level for which the agents might be appropriate as put forth by the 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations.

In taking a closer look at the options, Aldredge shared research from the 

 trials that indicatedruxolitinib (Opzelura; Incyte) may be a rapidly effective option. “When switched from vehicle to ruxolitinib, the proportion of patients with IGA 0/1 [Investigator’s Global Assessment score of 0 or 1] increased rapidly, and ​mean BSA decreased rapidly after 4 weeks,” she told attendees.

In addition, she noted the overall bioavailability of ruxolitinib cream is low (a fraction of that of the oral formulation)​, and the average steady-state trough plasma concentrations at the highest strength (1.5% twice daily) were less than 20% of ruxolitinib half-maximal inhibitory concentration for JAK2 inhibition in human whole blood assays.​ The data also found no correlations between concentrations at steady state and any hematological changes, except for a transient increase in platelets at week 2​.

These highlights bring up important issues that need to be considered in real-world patients, Aldredge noted. She le​d a thoughtful discussion of these issues with her breakout group.

Aldredge reviewed the long-term safety data for ruxolitinib reported in the TRuE AD1 and TRuE AD2 studies, which looked at 0.75% and 1.5% ruxolitinib cream compared with vehicle​. Researchers found low ruxolitinib plasma concentrations, she said. There were minimal application site reactions, and most reported AEs were considered unrelated to treatment. The most common AEs were upper respiratory tract infection and nasopharyngitis; there were minimal reports of notable serious infections, malignancies, MACE, and thrombotic events.

The patient and her parents considered the options presented and decided to initiate topical ruxolitinib 1.5%. The cream was applied twice daily to the affected areas. The patient was advised to continue with daily emollients and an oral antihistamine for breakthrough itching. After 8 weeks of treatment, there was a 50% reduction in EASI scores, indicative of significant improvement in eczema severity, Aldredge said. Similarly, the patient reported a marked reduction in pruritus as well as improved sleep. She had no applicationsite reactions and reported no AEs. Moreover, the parents reported treatment satisfaction as well as reduced anxiety concerning topical treatments.

​Aldredge’s group acknowledged the importance of addressing parents’ concerns when considering certain treatment options. Ultimately, leveraging research and data can help clinicians devise a thoughtful treatment plan to meet the patient’s needs and address parents’ concerns.

​Research continues to shed light on AD pathophysiology, and these new insights allow for increased treatment options for patients, according to the Horizons Chairs. The conversations within the breakout sessions pointed to an exciting time for research and new solutions. Based on the conversations, there is an increased dedication to finding the most appropriate, safe, and rapidly effective treatment for each patient by leveraging special issues like comorbidities, response, severity, and age.

AAAAI/ACAAI JTF Atopic Dermatitis Guideline Panel; Chu DK, Schneider L, Asiniwasis RN, et al. Atopic dermatitis (eczema) guidelines: 2023 American Academy of Allergy, Asthma and Immunology/American College of Allergy, Asthma and Immunology Joint Task Force on Practice Parameters GRADE- and Institute of Medicine-based recommendations. 

. 2024;132(3):274-312. doi:10.1016/j.anai.2023.11.009

Papp K, Szepietowski JC, Kircik L, et al. Long-term safety and disease control with ruxolitinib cream in atopic dermatitis: results from two phase 3 studies. 

. 2023;88(5):1008-1016. doi:10.1016/j.jaad.2022.09.060

Gong X, Chen X, Kuligowski ME, et al. Pharmacokinetics of ruxolitinib in patients with atopic dermatitis treated with ruxolitinib cream: data from phase II and III studies. 

. 2021;22(4):555-566. doi:10.1007/s40257-021-00610-x

Experts at the Horizons in Advanced Practice meeting discussed challenges and innovations in treating plaque psoriasis and atopic dermatitis (AD). A case study of a 12-year-old with moderate AD highlighted the use of topical ruxolitinib, which showed significant improvement in eczema severity and pruritus. The treatment landscape for AD includes various topical therapies, with ruxolitinib cream demonstrating low systemic absorption and minimal adverse effects. The meeting emphasized the importance of addressing patient and parent concerns, leveraging research to tailor treatment plans, and the ongoing advancements in AD management.

At the Horizons in Advanced Practice meeting, Lakshi Aldredge, MSN, ANP-BC, DCNP, FAANP, presented a case of a female patient aged 12 years with moderate AD that had been worsening over the past several months.

Michael Heile, MD, FAAFP

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