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and joined the MJH Life Sciences team in February 2023. She attended Kent State University and earned a Bachelor of Science degree in journalism with minors in public relations and creative writing. She enjoys making and listening to music, reading, and spending time with her cats, Astrid and Marceline.

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Catch up on dermatology news, highlights, and insights from the past 24 hours.

Daily Derm Times: April 22, 2025

Researchers conduct a review to understand the efficacy and safety of topical minocycline for the treatment of moderate to severe papulopustular rosacea.

Minocycline Foam Significantly Improves Papulopustular Rosacea Outcomes

Kaitlyn Bader is the assistant managing editor of 

 and joined the MJH Life Sciences team in June 2022. She attended Otterbein University in Westerville, Ohio, and earned a Bachelor of Arts degree in literary studies with minors in creative writing and film studies. Prior to health care news, Kaitlyn worked in industrial marketing. She enjoys cooking, reading, and tending to her house plants.

In a recent Dermatology Times Case-Based Peer Perspectives custom video series, Naiem Issa, MD, PhD, reviewed 3 complex patient cases of atopic dermatitis. 

Using Real-World AD Cases to Pick the Right Therapy for Each Patient

Maddi Hebebrand is an associate editor of 

and joined the MJH Life Sciences team in May 2024. She attended Baldwin Wallace University, studying Media Production and Film, and received her Masters in Digital Media from Ohio University. When she's not writing, Maddi loves to read, attend concerts and spend time with her family. 

Despite early psychological symptoms, over half of patients in the study completed their full treatment course.

Isotretinoin Often Continued Despite Mood Concerns

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Menopausal acne is rising yet underexplored; treatment must address hormonal shifts, skin sensitivity, and patient emotional well-being.

How to Best Support Women With Menopausal Acne

Final Thoughts: The Importance of Comparative Studies in AD

Panelists offer concluding insights and emphasize the critical role of comparative studies in advancing atopic dermatitis treatment strategies.

clinical

Video Series

A recent study reviewed cosmeceutical trends on social media and discovered that retinol is the most searched cosmeceutical on several platforms.

Investigators used analytics from TikTok and Google Trends. It is estimated that between 45% and 50% of adults turn to social media for skin care advice.

The authors conducted a Google Trends search from January 2004 to December 2023 in the United States. Trend lines were created for terms like retinol, bakuchiol, salicylic acid, glycolic acid, azelaic acid, hydroquinone, niacinamide, vitamin C serum, and hyaluronic acid. Then, the yearly perfect differences in relative search volume index (SVI) were calculated. The SVI is the ratio of the frequency a term is searched within a specific time relative to peak search volume during that time frame. An SVI of 100 is the peak popularity of the term. These trends were then graphed on scatterplots and compared to the total number of TikTok views for each search term.

The largest twofold increase in cosmeceutical search volume occurred from 2020 to 2021, due to the COVID-19 pandemic. Here, the average SVI doubled or tripled, with some increasing by 40% or more. Between 2022 and 2023, search volume rose by over 18%. This search interest in trends will continue to increase over time, according to the data.

Retinol was the most popular on both platforms followed by hyaluronic acid, salicylic acid, glycolic acid, vitamin C, niacinamide, hydroquinone, and azelaic acid. Retinol had an interest rank of 1 based on both Google SVI and TikTok views, the highest of all the cosmeceuticals. Bakuchiol was the least popular search term. Interestingly, niacinamide had much more TikTok views than Google searches. Conversely, salicylic acid had a higher Google SVI and a lower amount of TikTok viewership.

“Although not perfectly aligned, these data results collectively reveal that cosmeceutical appeal is constantly increasing, and that interest correlates with consumer viewership on social media,” the authors wrote.

The data may not accurately characterize all of the public interest due to some study limitations, including the lack of Internet access for older populations or those with lower socioeconomic status. Additionally, although Google Trends can be localized to certain geographic regions, TikTok cannot. Future literature could further evaluate specific demographics.

These results emphasize patients’ public interest in skin care, specifically with cosmeceuticals. Clinicians are advised to stay informed on popular social media trends so that they can educate their patients on product usage and combat misinformation.

“Awareness of skincare trends and growth in cosmeceutical interest empower dermatologists to anticipate patient inquiries and develop targeted education on product efficacy, cost effectiveness, and potential adverse reactions,” the authors wrote.

Let us know your thoughts and experiences by answering our poll above and commenting on social media, or by writing to us at 

1. Correia E, Mandel J, Cullison SRJ. Analyzing Social Media Trends in Cosmeceuticals: Insights From Google Trends and TikTok Analytics. 

. 2025;24(4):e70172. doi:10.1111/jocd.70172

2. Yousaf A, Hagen R, Delaney E, Davis S, Zinn Z. The influence of social media on acne treatment: A cross-sectional survey. 

2020;37(2):301-304. doi:10.1111/pde.14091

A study analyzed cosmeceutical trends on social media, revealing retinol as the most searched term on platforms like TikTok and Google. The research utilized Google Trends data from 2004 to 2023, showing a significant increase in search volume during the COVID-19 pandemic. Retinol, hyaluronic acid, and salicylic acid were among the top searched terms. The study highlights the growing public interest in cosmeceuticals and suggests that clinicians should stay informed about social media trends to educate patients effectively and address misinformation.

Google search trends and TikTok view counts were used to analyze the public popularity of cosmeceutical ingredients like retinol, hyaluronic acid, and niacinamide.

POLL: Which Cosmeceuticals Are Most Popular, According to Social Media?

This week is Hidradenitis Suppurativa Awareness Week.

POLL: What Percentage of the Population Has Hidradenitis Suppurativa?

 (Dupixent; Regeneron and Sanofi) for the treatment of chronic spontaneous urticaria (CSU) in patients aged 12 years and older who have not previously reached controlled disease status with H1 antihistamine treatment.

The approval marks the introduction of the first targeted therapy for CSU in more than a decade.

“[Dupilumab] is the first new targeted treatment for chronic spontaneous urticaria, or CSU, in over 10 years, with pivotal trials demonstrating its ability to help patients significantly reduce the hallmark symptoms of intense itch and unpredictable hives associated with this disease," said George D. Yancopoulos, MD, PhD,  board co-chair, president, and chief scientific officer at Regeneron. "With this FDA decision, [dupilumab] is now approved for 7 chronic, debilitating atopic conditions driven in part by underlying type 2 inflammation, several of which have been shown to co-morbidly occur with CSU, such as atopic dermatitis and asthma – providing patients with one treatment that might help multiple atopy conditions. We look forward to bringing [dupilumab] to the more than 300,000 CSU patients in the US with inadequately controlled disease on standard-of-care treatment who, until now, had limited treatment options.”

Dupilumab, an interleukin-4 (IL-4) and interleukin-13 (IL-13) inhibitor, has already been approved for multiple type 2 inflammatory conditions, including atopic dermatitis, asthma, eosinophilic esophagitis, and prurigo nodularis.

The approval comes after years of research and regulatory engagement. In October 2023, the 

 for the initial supplemental Biologics License Application (sBLA),

 stating that additional efficacy data were needed to support approval. However, the agency did not identify concerns regarding dupilumab’s safety or manufacturing process.

In response to the CRL, Regeneron and Sanofi resubmitted the sBLA, which was 

 That resubmission included updated efficacy and safety data from a third phase 3 trial, LIBERTY-CUPID Study C, in biologic-naïve patients with CSU uncontrolled by antihistamines.

LIBERTY-CUPID: Building the Case for Approval

The LIBERTY-CUPID (NCT04180488) clinical development program, which supported the approval, consisted of 3 randomized, double-blind, placebo-controlled phase 3 trials.

: Conducted in biologic-naïve CSU patients whose symptoms remained uncontrolled despite H1 antihistamine therapy.

: Conducted in patients who were not only uncontrolled on H1 antihistamines but also refractory or intolerant to omalizumab (Xolair; Novartis).

Across the trials, patients receiving dupilumab experienced significant improvements in CSU symptoms. In Study C, which provided the pivotal data for approval, nearly half of participants achieved well-controlled disease status, marked by meaningful reductions in itch severity and hives, compared with placebo. These findings aligned with earlier results seen in Study A, reinforcing the drug’s efficacy.

Adverse events observed during the studies were consistent with dupilumab’s known safety profile. The most common adverse effects included injection site reactions and COVID-19 infections, which occurred in both treatment and placebo groups. No new safety signals were identified.

Filling a Decade-Long Gap in CSU Treatment

Prior to today’s approval, patients with CSU who did not respond to H1 antihistamines had limited treatment options, most notably omalizumab, an anti-IgE monoclonal antibody.

Dupilumab’s approval fills this gap as the first new targeted therapy for CSU in more than 10 years, and the only approved biologic that inhibits IL-4 and IL-13 signaling, key drivers of type 2 inflammation.

"It’s been 10 years with no innovation for chronic urticaria… now to switch gears for a new approval that the dermatology specialists are familiar with… ultimately, the patients benefit," said Jason Hawkes, MD, MS, a board-certified dermatologist and co-owner, chief scientific officer, and investigator at the Oregon Medical Research Center in Portland, Oregon, in a 

"Most of these patients—around 50%—don’t respond to antihistamines, even at high-doses," Hawkes added.

The companies are expected to launch Dupixent for CSU in the near future.

"It's going to bring patients into a specialty dermatology that hasn't really been managing these patients. We're going to pick up new observations, new insights," Hawkes said. "Dermatology specialists are familiar and comfortable with this therapy. They use it for other indications, but now they have a familiar therapy for a disease that they know how to recognize but weren't historically treating. I think [dupilumab] comes into that landscape where they
have the comfort with the therapy that's had a very good safety record having, in some indications, approval down to even 6 months of age."

Dupixent® (dupilumab) approved in the US as the first new targeted therapy in over a decade for chronic spontaneous urticaria (CSU). News release. Globe Newswire. April 18, 2025. Accessed April 18, 2025. 

https://www.globenewswire.com/news-release/2025/04/18/3064133/0/en/Dupixent-dupilumab-Approved-in-the-U-S-as-the-First-New-Targeted-Therapy-in-Over-a-Decade-for-Chronic-Spontaneous-Urticaria-CSU.html

Regeneron and Sanofi provide update on Dupixent (dupilumab) SBLA for chronic spontaneous urticaria. News release. Regeneron Pharmaceuticals Inc. October 20, 2023. Accessed April 18, 2025. 

https://investor.regeneron.com/news-releases/news-release-details/regeneron-and-sanofi-provide-update-dupixentr-dupilumab-sbla

Dupixent (dupilumab) sBLA accepted for FDA review for the treatment of chronic spontaneous urticaria (CSU). News release. Regeneron. November 15, 2024. Accessed April 18, 2025. 

https://investor.regeneron.com/news-releases/news-release-details/dupixentr-dupilumab-sbla-accepted-fda-review-treatment-chronic

Dupilumab for the treatment of chronic spontaneous urticaria in patients who remain symptomatic despite the use of H1 antihistamine and who are naïve to, intolerant of, or incomplete responders to omalizumab (LIBERTY-CSU CUPID). ClinicalTrials.gov ID NCT04180488. Last updated December 11, 2024. Accessed April 18, 2025. 

https://clinicaltrials.gov/ct2/show/NCT04180488

Dupilumab becomes the first targeted therapy approved for chronic spontaneous urticaria in more than a decade.

FDA Approves Dupilumab for Adolescents and Adults With H1 Antihistamine-Refractory Chronic Spontaneous Urticaria

Cabtreo (Ortho Dermatologics; formerly known as IDP-126) was approved by the US Food and Drug Administration

 (FDA) in October 2023 for the treatment of patients aged 12 years and older with acne vulgaris. Cabtreo is the first FDA-approved fixed-dose triple-combination gel (clindamycin 1.2%/adapalene 0.15%/benzoyl peroxide 3.1%) for patients with acne. Cabtreo is expected to be available in Q1 of 2024.

, more than half (52.5%) of patients treated with Cabtreo achieved treatment success as measured by a 2-point or greater reduction from baseline in Evaluator’s Global Severity Score and clear or almost clear skin. In the first of the phase 3 trials, the proportion of patients treated with Cabtreo achieving clear or almost clear skin (49.6%) was significantly greater than patients being treated with a vehicle gel (24.9%). The second phase 3 trial demonstrated consistent significant rates of treatment success among Cabtreo- treated patients (50.5%) versus patients in the vehicle gel group (20.5%).

What are your thoughts about Cabtreo as the newest acne topical? Email us at 

Cabtreo, a fixed-dose triple-combination gel, received FDA approval in October 2023 for treating acne vulgaris in patients aged 12 and older. It combines clindamycin, adapalene, and benzoyl peroxide, marking the first such approved formulation. Clinical trials demonstrated its efficacy, with over half of the patients achieving significant improvement in acne severity. Phase 3 trials showed Cabtreo's superiority over a vehicle gel, with nearly 50% of patients achieving clear or almost clear skin. Cabtreo is anticipated to be available in the first quarter of 2024.

Click here to answer this week's acne poll.

Polls 

POLL: Have Your Patients Asked About Cabtreo for Acne?

Last week, our Hyperhidrosis Awareness Month poll

 challenged your knowledge of the prevalence of excessive sweating. We asked: What percent of the global population is estimated to have hyperhidrosis? 

, according to the International Hyperhidrosis Society. Despite how common hyperhidrosis is, it is estimated that 27% of those with the condition never receive a diagnosis.

Even more so, not everyone who experiences excessive sweating has shared their symptoms and experiences with a health care professional.

 wants to hear from you. What percent of those with hyperhidrosis have discussed their excessive sweating with a health care professional?

 to share your hyperhidrosis insights or research.

Doolittle J, Walker P, Mills T, Thurston J. Hyperhidrosis: an update on prevalence and severity in the United States. 

. 2016;308(10):743-749. doi:10.1007/s00403-016-1697-9

Click here to answer this week's poll for Hyperhidrosis Awareness Month.

Cameron Clements, NP-C

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