The Weekly Roundup: March 17-21

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Unraveling the Molecular Mechanism of Clindamycin Binding in Cutibacterium acnes and Resistance Development: Insights From Cryo-EM

Cryo-EM reveals molecular mechanisms of clindamycin resistance in Cutibacterium acnes, highlighting key mutations affecting antibiotic binding.

Povorcitinib Demonstrates Promising Phase 3 Results for Hidradenitis Suppurativa Treatment

Incyte’s phase 3 STOP-HS trials demonstrated significant efficacy and safety of povorcitinib in moderate to severe hidradenitis suppurativa.

Social Media “Hacks”: DIY Sunscreen, Slugging, and More With Chris Tomassian, MD

Tomassian noted unrealistic beauty standards fueled by social media filters and edited images have led to distorted expectations.

Climate Change, Pollution’s Growing Impact on Dermatology

Experts stressed the importance of dermatologists engaging in climate advocacy and adopting sustainable practices, as their actions may inspire others to follow suit.

Medical Device Ialuxid Gel Is Successful in Treating Mild to Moderate Acne

Patients observed a 56% reduction in lesions after 56 days of treatment with only mild adverse events.

Essential AAD Late Breakers That Could Change Your Practice

Explore a comprehensive roundup of the most important AAD late breakers, all in one place – key insights from the latest dermatology research.

Bridging the Gender Gap: Women Leading the Way

Join Dermatology Times in celebrating the women who make this field shine through their patient interactions, clinical insights, and research.

A Walk Through The AAD 2025 Poster Hall: The Must-See Research Shaping Dermatology

Discover the latest research from the AAD poster hall, compiled in one place for dermatology professionals.

Analyzing Current Procedures for Periorbital Hyperpigmentation

A comprehensive evaluation of therapies found that lasers were most effective with high rates of patient satisfaction.

Potential Treatments for TSW Identified in NIH Study

A pilot study revealed that mitochondrial complex I-blocking drugs, like metformin and berberine, improved TSW symptoms in most participants.

Thermus Thermophilus Fermentation Extract Can Treat Androgenic Alopecia

According to a clinical trial and in vitro study, TTFE can promote scalp health and hair growth by 96.88% while reducing inflammation.

Advancing Hidradenitis Suppurativa Care - Early Diagnosis, Biologic Therapies, and Multidisciplinary Approaches: Part 1

In part 1 of this Frontline Forum supplement, experts discuss the burden of HS, reducing diagnostic delays, and more.

Journal Digest: March 19

This review of the latest dermatologic studies includes insights into supporting laser tattoo removal for adults impacted by the justice-system, a case of blastic plasmacytoid dendritic cell neoplasm, and more.

Addressing the Challenges of Pigmentary Disorders in Women Across the Fitzpatrick Skin Spectrum

Valerie Harvey, MD, MPH, FAAD, discusses pigmentary disorders like melasma and hyperpigmentation, highlighting their disproportionate impact on women, particularly those with skin of color.

Multidisciplinary Approaches to Advanced BCC and CSCC

The expert discussion focused on patient management strategies, treatment modalities, and the role of multidisciplinary collaboration.

Patients and Providers Seek More Effective, Time-Saving Treatments for Seborrheic Dermatitis

According to a survey, both patients and clinicians are unsatisfied with the current therapeutic landscape and are looking for options that better fulfill patient needs.

Post Hoc Analysis Highlights Zasocitinib’s Efficacy Across Patient Groups

The investigational drug, designed using AI technology, optimizes pharmacologic characteristics for psoriasis treatment.

Novel Monopolar Radiofrequency Device is Effective and Safe for Facial Wrinkles

Participants experienced smoother, younger-looking skin after just 1 session, with results lasting up to 16 weeks.

Tezepelumab Shows Sustained Post-Treatment Benefit in Chronic Spontaneous Urticaria Despite Missed Primary Endpoint

Tezepelumab reduced CSU activity post-treatment through week 32, suggesting a delayed, sustained TSLP blockade effect.

The Power of Mohs Surgery for Dermatofibrosarcoma Protuberans

A 30-year-old patient with dermatofibrosarcoma protuberans faced a recurrence after initial surgery. Mohs micrographic surgery was used for precise excision, reducing recurrence risk and improving outcomes.

Multidisciplinary Approaches to Managing Challenging Basal and Squamous Cell Carcinomas

John Strasswimmer, MD, PhD, spoke on the difficulty of managing adverse effects, the role of interdisciplinary clinical relationships, and the challenges in complex and older patients.

Phase 1 Trial of PKM2 Modulator SYX-5219 for Atopic Dermatitis Underway

The phase 1a study is a first in-human trial evaluating SYX-5219 for AD.

Dupilumab and AD: Pediatric Ocular Adverse Effects

A recent study highlights the need for ophthalmologic monitoring in pediatric dupilumab therapy.

Long-Term Safety and Efficacy of Ixekizumab in Japanese Patients with Psoriasis

This real-world data explores the use of the IL-17A blocker for up to 3 years in several subtypes of psoriasis.

New Research Confirms Effective Therapy for Nail Psoriasis

Nail psoriasis affects 50% of plaque psoriasis patients, making effective treatments crucial.

Review Findings Suggest Melanoma and Hidradenitis Suppurativa Are Risk Factors for Completed Suicide

The review also found that female patients with non melanoma skin cancer demonstrated a greater risk of completed suicide compared to members of a control group.

Anticipated Changes in Estate Planning for 2025 What Dermatologists Need to Know

Key estate planning changes in 2025: potential tax law shifts, federal exemption sunset, retirement account rules, state death taxes, and cryptocurrency issues.

Photosensitizing Drugs, Estrogen, and Diuretics Linked to Increased Skin Cancer Risk

Estrogen therapy and certain diuretics may increase skin cancer risk, highlighting the need for careful patient counseling and sun exposure management.

730-nm Picosecond Laser Is More Effective Than 1064-nm for Acquired Dermal Melanocytosis

The 730-nm picosecond laser had an efficacy rate of 88% with higher patient satisfaction compared to the 1604-nm wavelength.

Advancing Hidradenitis Suppurativa Care - Early Diagnosis, Biologic Therapies, and Multidisciplinary Approaches: Part 2

In part 2 of this Frontline Forum supplement, experts discuss current and emerging treatments, digital tools and supports, and more.

Supporting Reentrants: A Medical Student Volunteer Initiative

Participants reported increased confidence in clinical interactions and greater interest in dermatology as a career path.

Ritlecitinib Demonstrates Effectiveness in Subgroup Analysis of Asian Patients

At week 24, the proportion of Asian patients achieving significant hair regrowth (SALT ≤20) was substantially higher in ritlecitinib treatment groups than in placebo groups.

Q&A: How the PWRS Program and Inaugural Report is Empowering Women and Transforming Global Healthcare

Eve Arnera and Thandiwe Munaiwa, MD, spoke about the groundbreaking collaboration between SkinCeuticals and ReSurge International, “Pioneering Women in Reconstructive Surgery.”