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  • Drug Watch
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The Weekly Roundup: April 10-14


ICYMI, this week we had stories about melanoma management with pembrolizumab, advances in rosacea therapy, new phase 2 data of VP-315 for BCC, and more.

POLL: What Disease is Associated with Dermatitis Herpetiformis?

Click here to answer this week's poll.

The Mainstream Patient: April 10

This week's edition of the Mainstream Patient features stories about filler fatigue in 2023, the difference between RF microneedling and traditional microneedling, IPL hair removal devices, and more.

Preventing Laser, Light Therapy-Induced Lesions in Vitiligo

Researchers said laser and intense pulse light-induced vitiligo lacks consensus in prevention and safety measures.

Spring into Rejuvenated Goals in Your Practice

Now that we’re 4 months into 2023, many New Year’s resolutions have ended up in the rearview mirror.

Asthma, Eczema Associated With Higher Risk for Osteoarthritis

The study suggests that treatments for allergic reactions could help decrease the risk of having joint problems.

Millennials, Gen Xers Increase Risk of Nonmelanoma Skin Cancer

A new survey found that the demographics are not following safe sun habits and have low skin cancer awareness.

Phase 2 Trial of ADX-629 Underway for Treatment of AD

ADX‑629 also is being evaluated in Phase 2 clinical trials for the treatment of chronic cough, idiopathic nephrotic syndrome, and Sjögren-Larsson Syndrome.

Gut Health and Its Impact on the Skin

The gut-brain-skin axis is more important to overall health than previously understood, and prebiotics and probiotics play a large role in the benefits.

POLL: What is Your Go-To Treatment Recommendation for Rosacea?

Click here to answer this poll related to Rosacea Awareness Month.

Izokibep Demonstrates Statistically Significant Improvements in Psoriatic Arthritis

Researchers said the drug was also well-tolerated in patients.

The Amazing Skin Microbiome

The skin microbiome varies from person to person based on sex, age, body location, antimicrobial peptide presence, and immune function.

New Study Suggests Invasive Weed Could Have Anti-Aging Properties

The study was the first to examine the fruit's properties as a wound-healing agent and skin protectant.

Breaking Down Treatment and Management Options in Vitiligo​

Despite a lack of FDA-approved treatments and management options for patients with vitiligo, both dermatologists and patients alike have options for care.

Lipid-Lowering PCSK9 Inhibitors May Reduce Psoriasis Risk

The association between psoriasis and dyslipidemia is well established, although pathogenic pathways are not yet understood.

First Dosing of Patient in Phase 2 Study Evaluating VP-315 for BCC

Verrica Pharmaceuticals is developing a potentially first-in-class oncolytic peptide.

44% of Cosmetic Users Experience Negative Side Effects

Researchers in a recent study said women are more likely to experience these effects, which can affect internal health.

Neoadjuvant-Adjuvant Pembrolizumab Better Than Adjuvant-Only in Melanoma

The PD-1 inhibitor pembrolizumab has proven its efficacy in a number of different cancers.

Pointers With Portela: Are Made-to-Fade Tattoos Safe?

In this week’s Pointers with Portela, the 208SkinDoc discusses the safety of made-to-fade tattoos.

Microbial Diversity Leads to Successful Isotretinoin Response in Acne

Researchers said the drug successfully altered C. acnes strains and more in a recent study.

Pembrolizumab Plus Lenvatinib Phase 3 Melanoma Trial Discontinued

Merck and Eisai discontinued the trial based on recommendations of an independent data monitoring committee.

Almirall to Assess Patient Wellbeing in New Dermatology Study

This will be the first clinical study in dermatology to assess patients’ wellbeing as a primary endpoint.

Important and Upcoming Developments in Psoriasis

Researchers compiled future research directions and therapeutic and clinical developments in psoriasis.

FDA Clears Brella SweatControl Patch for Reduced Primary Axillary Hyperhidrosis

Patients can achieve reduced excessive underarm sweating after one in-office treatment.

Vitamin D has no Significant Impact on Psoriasis Severity

Oral vitamin D supplementation does not appear to have an effect on disease severity for those with low 25-hydroxyvitamin D (25[OH]D) levels.

The JAK Inhibitor Pipeline Builds in Dermatology

Eight JAK inhibitors are approved by the FDA to treat autoimmune, inflammatory, and allergic conditions.

Advances in Rosacea Therapy

April is National Rosacea Month. Recent data has indicated a correlation between rosacea and certain cardiovascular, neurologic, endocrine, and gastrointestinal disorders. Steve Daveluy, MD, FAAD, shares insight on that, plus several new and exciting therapies available.

Emerging Pathogens in Infectious Dermatoses

Researchers said several geographic and demographic factors or changes have led to new skin manifestations.

The Role of Beeswax in Supporting the Skin Barrier

A review of prior research shows that topical beeswax may have several dermatologic benefits.

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