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Maddi Hebebrand is an associate editor of 

and joined the MJH Life Sciences team in May 2024. She attended Baldwin Wallace University, studying Media Production and Film, and is now finishing her Masters in Digital Media through Ohio University. When she's not writing, Maddi loves to read, attend concerts and spend time with her family.

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Explore the top headlines of the week including insights on the environmental impact of conferences, new clinical data, and the shift towards more natural-looking results.

Dermatology Times' Sunday Crossword: March 16, 2025

Marie Bosslett is the assistant editor of 

 and joined the MJH Life Sciences team in October 2024. She attended Loyola University Maryland in Baltimore and earned a Bachelor of Arts in Communication with minors in marketing and writing. When she’s not writing, Marie enjoys going to concerts, reading on the beach, and spending time with friends and family.

In case you missed it, this week we had news about the FDA voluntary benzoyl peroxide recalls, the National Eczema Association's strategic efforts, recaps of this week’s AAD Annual Meeting, and more. 

The Weekly Roundup: March 10-14

This week, we feature top articles from our sister publications on FDA updates, Medicaid pricing, and more.

The Rx Recap: March 9-15

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Assessing the Relationship between Psoriasis and Psoriatic Arthritis

Final Thoughts: The Importance of Comparative Studies in AD

Panelists offer concluding insights and emphasize the critical role of comparative studies in advancing atopic dermatitis treatment strategies.

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Video Series

Cabtreo (Ortho Dermatologics; formerly known as IDP-126) was approved by the US Food and Drug Administration

 (FDA) in October 2023 for the treatment of patients aged 12 years and older with acne vulgaris. Cabtreo is the first FDA-approved fixed-dose triple-combination gel (clindamycin 1.2%/adapalene 0.15%/benzoyl peroxide 3.1%) for patients with acne. Cabtreo is expected to be available in Q1 of 2024.

, more than half (52.5%) of patients treated with Cabtreo achieved treatment success as measured by a 2-point or greater reduction from baseline in Evaluator’s Global Severity Score and clear or almost clear skin. In the first of the phase 3 trials, the proportion of patients treated with Cabtreo achieving clear or almost clear skin (49.6%) was significantly greater than patients being treated with a vehicle gel (24.9%). The second phase 3 trial demonstrated consistent significant rates of treatment success among Cabtreo- treated patients (50.5%) versus patients in the vehicle gel group (20.5%).

What are your thoughts about Cabtreo as the newest acne topical? Email us at 

Cabtreo, a fixed-dose triple-combination gel, received FDA approval in October 2023 for treating acne vulgaris in patients aged 12 and older. It combines clindamycin, adapalene, and benzoyl peroxide, marking the first such approved formulation. Clinical trials demonstrated its efficacy, with over half of the patients achieving significant improvement in acne severity. Phase 3 trials showed Cabtreo's superiority over a vehicle gel, with nearly 50% of patients achieving clear or almost clear skin. Cabtreo is anticipated to be available in the first quarter of 2024.

Click here to answer this week's acne poll.

Polls 

POLL: Have Your Patients Asked About Cabtreo for Acne?

The American Academy of Dermatology (AAD) recently released new 

 to update the previous 2016 guidelines. The AAD Acne Workgroup made strong recommendations for topical benzoyl peroxide, retinoids, and/or antibiotics and their fixed-dose combinations, and for oral doxycycline.

 also reviewed topical retinoids, including tretinoin, adapalene, trifarotene, and tazarotene.

“We recommend topical retinoids for acne treatment based on moderate certainty evidence from 20 studies. Compared to vehicle at 12 weeks, a greater proportion of patients treated with topical retinoids achieved IGA success in 4 RCTs (risk ratio [RR], 1.57 [1.21, 2.04]). Existing comparative effectiveness data do not suggest superiority of one topical retinoid against another, with efficacy and tolerability differing by specific concentrations and formulations,” wrote Reynolds et al.

Reynolds RV, Yeung H, Cheng CE, et al. Guidelines of care for the management of acne vulgaris. 

. Published online January 30, 2024. doi:10.1016/j.jaad.2023.12.017

Tell us more about what retinoids you prescribe and why by emailing 

The American Academy of Dermatology has updated its acne treatment guidelines, emphasizing the use of topical benzoyl peroxide, retinoids, and antibiotics, as well as oral doxycycline. The guidelines highlight the efficacy of topical retinoids such as tretinoin, adapalene, trifarotene, and tazarotene, based on moderate certainty evidence from multiple studies. The data indicate no significant superiority among different retinoids, with efficacy and tolerability varying by concentration and formulation. These updates aim to provide dermatologists with evidence-based recommendations for managing acne vulgaris effectively.

Click here to answer this week’s acne poll. 

POLL: What Topical Retinoid Do You Most Often Prescribe? 

To stay informed with the latest conference insights,

Icotrokinra Demonstrates Promise in Phase 3 ICONIC-LEAD and ICONIC-ADVANCE for Plaque Psoriasis

Johnson & Johnson’s JNJ-2113 showed promise for PsO, achieving high skin clearance with a strong safety profile.

InflaRX Presents Efficacy and Safety Data on Vilobelimab at AAD 2025

Efficacy, safety, and pharmacokinetic data support the use of vilobelimab in treating pyoderma gangrenosum and hidradenitis suppurativa.

Reviewing 3 Key Lebrikizumab Abstracts From AAD 2025

Anabela Cardoso, MD, discussed lebrikizumab’s efficacy in improving itch, skin pain, sleep disturbance, and long-term management in atopic dermatitis.

Lebrikizumab Shows 3-Year Sustained Efficacy in AD

The study found half of the patients receiving once-monthly lebrikizumab achieved complete skin clearance at 3 years, with 87% maintaining near-clearance.

Michael Gold, MD: Advances in Acne Treatment and Energy-Based Devices

Gold highlighted the growing role of energy-based devices in acne treatment during his AAD session.

Late-Breaking ESK-001 Data from the OLE STRIDE Trial Presented at AAD 2025

New results from Alumis show a positive clinical response and safety profile after 52 weeks of treatment for patients with plaque psoriasis.

Addressing Ongoing Benzoyl Peroxide and Benzene Updates at AAD 2025

Christopher Bunick, MD, PhD, discussed how to interpret recent benzene research as clinicians await regulatory guidance for benzoyl peroxide.

Catch up on coverage from the final day of the 2025 American Academy of Dermatology Annual Meeting held in Orlando, Florida.

Day 5 Recap: AAD 2025

The lip augmentation market is projected to reach a value of 11.6 billion USD by 2030.

 Although hyaluronic acid fillers are the most common type of lip procedure, an alternative method, the “lip flip,” has grown in popularity in recent years, with the #lipflip hashtag gaining 64.4 million views on TikTok as of July 2021.

 A lip flip involves injecting botulinum neurotoxin A (BoNT-A) into the superior orbicularis oris muscle, forming a more natural “pout” in the upper mouth. The technique is less expensive than a traditional dermal lip filler, but the effects have a more temporary duration of 8 to 12 weeks. Both methods have similar adverse effects of swelling and bruising at the injection site, but lip flips do not require much aftercare post-procedure.

“’Lip flips’ are ideal for patients who desire fuller lips but do not want lip fillers, have excessive gingival display while smiling, have an upper lip that retracts with their smile, or prefer relatively short-term or temporary results,” according to the study authors.

A novel longitudinal analysis evaluated shifts in public interest over the past decade regarding these minimally invasive lip augmentation strategies.

 Investigators used the Google Trends database to evaluate the historical monthly search volumes of “lip filler” and “lip flip” from January 2014 to January 2024.

Both search terms had similar increases in engagement across the 10-year period. However, lip filler was searched more consistently with an average 75% increase in relative search volume per month. Conversely, lip flip had a mean increase of 33%. Furthermore, the relative search volumes were quantified as 12.1 for lip flip and 30.4 for lip filler, giving “lip flip” a consistently lower Google search volume over time (

Even with these differences, both terms saw similar patterns across the years. For example, both saw a rapid decline at the onset of the COVID-19 pandemic,  between February 2020 and April 2020. Conversely, between September 2022 and February 2023, there was a stark increase in both categories' searches.

Even as lip flips grow in public interest, it still remains secondary to lip filler, according to this data. The research is limited, however, as the sole use of Google Trends does not provide information on patient factors like demographics, satisfaction, and outcomes. Including clinical surveys and data in future research could bolster these results and provide a more nuanced perspective on these procedures.

“This reveals a need for future research surrounding patient and physician education on minimally invasive lip augmentation procedures and what deciding factors are considered, such as safety, cost, or convenience,” the authors concluded. “It also emphasizes the need for future research assessing sociodemographic factors that play a role in cosmetic lip augmentation, ultimately allowing us to understand better the populations seeking these procedures and their accessibility.

Do you prefer lip filler or lip flips? Let us know your thoughts and experiences by answering our poll above and commenting on social media, or by writing to us at 

1. Grandview Research, “Lip Augmentation Market Size to Reach $11.61Bn By 2030,” (2023), 

https://www.grandviewresearch.com/press-release/global-lip-augmentation-market.

2. D. Shira, “Considering a Lip Flip? Here's Why Experts Say Proceed With Caution,” (2024), 

www.forbes.com/sites/dahvishira/2024/02/21/considering-a-lip-flip-heres-why-experts-say-proceed-with-caution/

3. Bourmand R, Olsson SE, Soleimani S, Fijany A. Lip Filler Versus "Lip Flip": Longitudinal Public Interest and a Brief Review of Literature. 

. 2025;24(2):e70048. doi:10.1111/jocd.70048

The lip augmentation market is expected to reach $11.6 billion by 2030, with hyaluronic acid fillers being the most common procedure. However, the "lip flip," which uses botulinum neurotoxin A, is gaining popularity due to its natural appearance and lower cost, despite its temporary effects. A longitudinal analysis using Google Trends showed that while both "lip filler" and "lip flip" searches increased over the past decade, lip fillers consistently had higher search volumes. The study highlights the need for further research on patient demographics and satisfaction to better understand these procedures.

Share your thoughts by answering today’s poll and read about these popular aesthetic techniques for lips.

POLL: “Lip Flips” or Lip Filler? Analyzing the Latest Trends in Lip Augmentation 

It is time to consider non-pulse dye lasers in pediatric populations, Deepti Gupta, MD, shared at the Society for Pediatric Dermatology 37th Annual Pre-AAD Annual Meeting in Orlando, Florida.

 Gupta, a pediatric dermatologist at Seattle Children's Hospital and the University of Washington School of Medicine, provided a comprehensive overview of the role of lasers in pediatric dermatology. Her presentation focused on the use of laser hair removal for various medical conditions in pediatric patients, emphasizing both the therapeutic benefits and practical considerations of laser treatments in this population.

Although many pediatric dermatologists are familiar with pulse dye lasers, the use of non-pulse dye lasers, such as Alexandrite and diode lasers, remains less widespread, Gupta explained. She underscored the potential of these lasers as valuable tools for treating conditions such as congenital birthmarks, pigmented lesions, scarring, and hair removal in pediatric patients with underlying medical conditions.

Laser's role in broadening the pediatric toolbox

One of the key takeaways from Gupta’s session was the importance of tailoring laser treatments to the unique needs of pediatric patients. Unlike adults, children require additional considerations regarding pain management, tolerability, and treatment logistics. She emphasized the need for a multidisciplinary approach, involving the right support team to ensure safe and effective treatments.

Gupta also addressed concerns regarding the potential side effects of laser treatments in pediatric patients, including risks of dyspigmentation, blistering, and scarring. She posed critical questions regarding the long-term efficacy of early laser interventions, such as whether treatment in childhood increases the likelihood of recurrence or provides lasting results.

A crucial aspect of laser therapy, she noted, is engaging in shared decision-making with families. Educating patients and caregivers about the number of sessions required, expected discomfort, and potential outcomes helps set realistic expectations. She compared laser treatments to alternative modalities, such as surgical excision, highlighting how lasers may reduce surgical morbidity and improve long-term cosmetic outcomes. By sharing the pros and cons with families, clinicians can empower them to make the best treatment decision for the child.

Reflecting on the broader landscape of pediatric dermatology, Gupta expressed enthusiasm about the increasing availability of US Food and Drug Administration-approved treatments for chronic pediatric dermatologic conditions. She is eager to see how expanding therapeutic options, including both lasers and systemic treatments, will shape the future of pediatric dermatology.

Beyond the clinical insights, Gupta emphasized the value of the AAD Annual Meeting as a forum for knowledge exchange and collaboration. Like many others, she appreciates the opportunity to engage with fellow dermatologists, learn about emerging advancements, and collectively enhance patient care.

Gupta said she hoped her session would help clinicians better understand the evolving role of lasers in pediatric dermatology, and she encouraged dermatologists not to shy away from integrating these tools into their practice, ultimately expanding treatment options and improving patient outcomes.

2025 American Academy of Dermatology Annual Meeting

1. Gupta D. "Beyond PDL: Lasers for the Pediatric Dermatologist." Presented at: Society for Pediatric Dermatology 37th Annual Pre-AAD Annual Meeting; March 6, 2025; Orlando, Florida.  

Deepti Gupta, MD, highlighted the potential of non-pulse dye lasers, such as Alexandrite and diode lasers, in pediatric dermatology, particularly for conditions like congenital birthmarks and pigmented lesions. She emphasized the importance of tailoring treatments to pediatric needs, considering pain management and treatment logistics. Gupta also discussed the necessity of shared decision-making with families, addressing potential side effects and comparing laser treatments to surgical alternatives. She expressed optimism about the expanding therapeutic options in pediatric dermatology and encouraged clinicians to integrate lasers into their practice for improved patient outcomes.

Deepti Gupta, MD, discussed the importance of lasers at the Society for Pediatric Dermatology 37th Annual Pre-AAD Annual Meeting.

Braulio Gomez, MD, Head of Dermatology Medical Affairs at UCB

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