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Rapid Itch Reduction Data With Tapinarof in AD


Raj Chovatiya, MD, PhD, and Adelaide A. Hebert, MD, FAAD, discuss the rapid itch reduction results found in the clinical trials for tapinarof in AD, as well as primary end points of the studies.

This is a video synopsis/summary of a panel discussion involving Raj Chovatiya, MD, PhD, and Adelaide A. Hebert, MD, FAAD.

The transcript discusses data related to the rapid reduction of itching in patients with atopic dermatitis using tapinarof. The primary focus is on the speed and effectiveness of itch relief, challenging the traditional belief that non-steroidal treatments are less effective than steroids.

Adelaide emphasizes the novelty and excitement of achieving rapid itch reduction within 24 hours after the first application of tapinarof. The data, presented in ADORING 1 and ADORING 2, demonstrates sustained and continuous improvement in itch relief over 14 days. The comparison with the vehicle indicates a significant delta, showcasing tapinarof's superiority in rapid itch reduction.

The speakers discuss the importance of early and substantial improvement in itch, noting that such results can positively impact patient adherence to treatment. The data indicates that by the end of the 8-week period, both ADORING 1 and ADORING 2 show a meaningful reduction in peak pruritus numerical rating scale (NRS), with tapinarof outperforming the vehicle.

The conversation underscores the clinical importance of reducing itch in patients with moderate to severe atopic dermatitis and suggests that such improvements can positively influence patients' commitment to treatment regimens. The discussion on delta values emphasizes the statistical significance of the findings, providing confidence in tapinarof’s efficacy.

The speakers also highlight the consistency in the data between ADORING 1 and ADORING 2, suggesting predictability in patient responses. The transcript concludes with an exploration of the peak pruritus NRS response and the achievement of study endpoints in both trials. Overall, the data presented in the transcript suggests that tapinarof holds promise as an effective and rapid-acting treatment for atopic dermatitis.

Video synopsis is AI-generated and reviewed by Dermatology Times editorial staff.

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