Los Angeles - Azathioprine is an effective treatment for severe atopic dermatitis in adults, although it can be poorly tolerated by some patients due to gastrointestinal side effects, and careful laboratory monitoring is indicated because of its potential to cause hematologic and hepatic toxicity, according to results of a randomized, double-blind, placebo-controlled, crossover study.
The FDA approval, based on 36-week data from the phase 3 BRAVE-AA-PEDS trial, extends baricitinib access to patients as young as 12 years old with severe alopecia areata.