Research has shown that the DESCRIBE perfluorodecalin (PFD) patch (Merz) can be used to safely and effectively enhance the tattoo removal process for patients by allowing multiple passes in a single laser treatment session.1 It has also shown that the patch improves treatment tolerability.2 However, research has yet to examine the effects the PFD patch has on thermal injury of the epidermis — until now.
Adding another layer to this growing body of research, Wojciech Danysz, Ph.D., Merz Pharmaceuticals, provided recent study data on the PFD patch and evaluation of thermal injury and plume, in a poster, at this year’s annual meeting of the American Academy of Dermatology (AAD) in Washington DC.3
PFD Patch Background
The PFD patch, which has been on the market since 2015, was initially FDA-cleared for use as an accessory to laser tattoo removal procedures using a 755 nm Q-Switched Alexandrite laser in Fitzpatrick Skin Type I-III patients. The patch received a new clearance in 2017, expanding to approved use with 532 nm, 694 nm, 755 nm and 1,064 nm standard Q-Switched lasers as well as 532 nm, 755 nm, 785 nm and 1,064 nm standard picosecond lasers in Fitzpatrick Skin Type I-III patients.
The PDF patch works by minimizing the time epidermal whitening remains on the laser treatment area. As a result, multiple passes during a single treatment session are possible, which can help to reduce the number of treatment sessions a patient may need for effective tattoo clearance.
“Every time you treat a tattoo, there is some epidermal whitening. That is the endpoint that we look for as the successful treatment of a tattoo. But when the epidermal whitening is present, it actually limits us from continuing the treatment because you are adding thermal damage while only minimally continuing to break down the tattoo ink,” according to Dr. Tsao, as reported by Dermatology Times in a previous article.4
In 2017, Biesman and Costner demonstrated improved tolerability with the PFD patch in terms of patients having fewer and less severe adverse events related to epidermal injury compared with conventional laser tattoo removal treatment.2
Dr. Danysz is an employee of Merz Pharmaceuticals.
- Biesman BS, O'neil MP, Costner C. Rapid, high-fluence multi-pass q-switched laser treatment of tattoos with a transparent perfluorodecalin-infused patch: A pilot study. Lasers Surg Med. 2015;47(8):613-8.
- Biesman BS, Costner C. Evaluation of a transparent perfluorodecalin-infused patch as an adjunct to laser-assisted tattoo removal: A pivotal trial. Lasers Surg Med. 2017;49(4):335-340.
- Danysz, W. Evaluation of the Perfluorodecapin Patch for Laser Tattoo Removal in a Pig Model to Evaluate Thermal Injury Protection and Plume.” Poster. The Annual Meeting of the AAD. Washington DC: 2019.
- Top 3 trends for tattoo removal. Dermatology Times. September 6, 2016. Available at: https://www.dermatologytimes.com/dermatology/top-3-trends-tattoo-removal Accessed April 1, 2019.
- Vangipuram R, Hamill SS, Friedman PM. Perfluorodecalin-infused patch in picosecond and Q-switched laser-assisted tattoo removal: Safety in Fitzpatrick IV-VI skin types. Lasers Surg Med. 2019;51(1):23-26.