Atopic Dermatitis

In this Medical News Minute, Dr. Lazzara discusses the findings of a recent study that examined the dosage of an experimental drug for the treatment of itchy skin in people with atopic dermatitis.

Dermatologists should not depend on a rescue approach for atopic dermatitis flares, says a recent paper. Instead, they should talk with patients about newer treatment options that could offer long-term disease with minimal adverse events.

The realization of the critical importance of the IL-17 and 23 pathways have led to the development of numerous therapies that target parts of the immune system.

Insights offer greater understanding around patient perspectives and desires that could prove useful to dermatologists in managing atopic dermatitis and psoriasis.

LEO Pharma has submitted an Investigational New Drug Application (IND) to the U.S. Food and Drug Administration (FDA) for the study of an oral atopic dermatitis treatment, JW1601/LP0190, according to a company announcement. 

Research suggests that early-, mid-, and late-onset pediatric AD may be clinically distinct disease subtypes and that age of onset could be used to risk stratify patients.

Wet wraps can improve moderate-to-severe atopic dermatitis, but little research has explored the impact of different topical corticosteroid vehicles on efficacy and patient tolerability. Here's what researchers discovered when they compared creams and ointments as vehicles for corticosteroid wet wraps in atopic dermatitis patients.

In this video, Dr. Lazzara discusses a study that examined operational definitions of atopic dermatitis in the literature, and their potential effect on prevalence and associated risk factors.

Twenty-five percent of adults with atopic dermatitis report the disease started in adulthood. Yet, diagnosing adult-onset atopic dermatitis can challenge even expert clinicians. Here's what you need to know.

The narrative about food, diet and atopic dermatitis recently changed significantly after publication of the Learning Early About Peanut study, says Peter Lio, M.D. Diet matters, and he discusses in what ways.

Researchers treated 22 patients with facial dermatitis and noted significant decreases in disease severity in four scores assessed. According to researchers, this study offers first proof of efficacy for black tea dressing treatment.

Researchers assessed levels of inflammatory and cardiovascular risk proteins in the blood of 30 children under five who had been diagnosed with moderate-to-severe atopic dermatitis and found that systemic immune activation is present within months of atopic onset.

Rajani Katta, M.D., shared some of the new triggers for contact dermatitis at this weekend's Society for Pediatric Dermatology Annual Meeting in Austin, Texas. With a practice nearly exclusively dedicated to treating this condition, she's seen a rising number of cases related to essential oils and flavorings.

While topical therapies may suffice for mild-to-moderate atopic dermatitis, systemic agents may become necessary for more severe disease. Peter Lio, M.D., discusses his approach to treatment utilizing available therapies.

Crisaborole ointment, 2%, (Eucrisa, Pfizer) appears to be safe and effective in children aged three months to less than 24 months who have mild-to-moderate atopic dermatitis, according to results of a phase 4 trial released yesterday.

Researchers tested whether diluted bleach solution at the concentrations recommended for bleach baths is an effective antibacterial agent.

In this Medical News Minute, Dr. Bobby Lazzara discusses the specifics regarding injection site reactions.

Are you training your patients on how to use their self-injectable medications safely and effectively? If not, you may want to start, according to researchers of a recent study, which examined patient behavior surrounding self-injection devices.

As a class, JAK inhibitors look like the best oral targeted therapeutic option when topical cortical steroids and/or topical calcineurin inhibitors plus emollients fail.

In our first Irregular Borders column, Peter A. Lio, M.D., explores the evidence for leaky gut and its relevance in dermatology while highlighting parallels with impaired skin barrier function in conditions such as atopic dermatitis.

Because a patient’s atopic dermatitis may also have a profound effect on parental caregivers, clinicians should seek to make an assessment of parental emotional and psychosocial well-being, and offer patient educational materials to help bring awareness to the issue.

Have you ever found yourself on the other side of the stethoscope? That’s what happened when Dr. Wheeland awoke one day with an asymptomatic, solitary, round, scaly patch on his ankle. Read how this experience inspired him to take a second look at how he treats patients with eczema.

“Pretty much, I couldn’t go about my normal life,” says Benjamin Sun about a life-altering eczema flare up at age 9, which left him out of school and bedridden for weeks. Until now, children like Sun didn’t have an effective, safe option for long-term disease control. Read how dupilumab changed his quality of life, and what it can do for your pediatric patients with uncontrolled moderate to severe atopic dermatitis.

Despite evidence that topical cannabinoids may relieve symptoms, more research is needed.

The differential diagnosis of atopic dermatitis can be challenging. Our expert, Dr. Robert Lazarra, highlights the basic criteria you need to know in this video.

Mothers of children with atopic dermatitis may be more likely to experience difficulty falling asleep, insufficient sleep and daytime exhaustion, according to a recent study. 

Unlike prior generations of dermatologic drugs, Janus kinase (JAK) inhibitors show potential for treating numerous dermatologic indications. Brett King, M.D., Ph.D. explored what this class of drug has to offer in his presentation during AAD earlier this month.

In the future, atopic dermatitis (AD) may need to be targeted with different drugs and tailored for different AD populations, particularly if initial treatment targeting all phenotypes fails, says Emma Guttman-Yassky, M.D., Ph.D.