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Bob Roehr is a medical writer based in Washinton, D.C.
September 01, 2012
Ultraviolet B (UVB) radiation damage to noncoding RNAs in keratinocytes initiates a cascade of events leading to the release of tumor necrosis factor-alpha (TNF-alpha), a cytokine central to the inflammatory skin response commonly known as sunburn. The surprising discovery of this mechanism has potential implications for better understanding of prevention, carcinogenesis and phototherapy, researchers say.
August 01, 2012
The hedgehog inhibitor drug vismodegib (Erivedge, Genentech/Roche), approved in January to treat advanced and metastatic basal cell carcinoma, has demonstrated potent clinical activity when used in patients with basal cell nevus syndrome, according to a study published recently in the New England Journal of Medicine.
July 01, 2012
New research has identified the signaling pathway through which mechanical forces play a major role in the fibrotic process of wound healing and scarring. Modulating this pathway in mice significantly reduced scarring and may offer a therapeutic target to reduce scarring in humans, says Geoffrey C. Gurtner, M.D.
Dermatologists have the highest level of job satisfaction of 25 medical specialties, according to a national survey conducted by Medscape titled Physician Compensation Report 2012. Dermatologists also are among the better compensated, particularly when their more-varied pattern of hours worked are taken into consideration.
A single intracellular molecule, activator protein-1 (AP-1), appears to initiate the signaling cascade for vascular remodeling that results in varicose veins. Assuming that these findings on the mechanisms of the disease in a mouse model translate into humans, they offer new targets for therapeutic intervention that go beyond current surgical options, a researcher says.
January 01, 2010
A new study supports speculation that exposure to low level laser therapy may stimulate proliferation of melanoma cells.
November 01, 2009
The Merkel cell polyomavirus (MCPyV), first identified in rare aggressive Merkel cell carcinoma in 2008, has now been isolated in up to a third of patients with squamous cell carcinoma (SCC), according to a new study published online in the Journal of Investigative Dermatology.
October 01, 2009
World report - Darker-skinned patients with morphea and related diseases are as likely to benefit from ultraviolet (UV) light therapy as patients with lighter skin. Some clinicians had speculated that the increased level of melanin found in darker skin might impede UV-A1, but that does not appear to be the case.
September 01, 2009
People and their pets are often said to take on the morphology and mannerisms of each other over time. Regardless of whether that is true, it's clear that they do come to share diseases, and, increasingly, that means methicillin-resistant Staphyloccus aureus (MRSA).
August 01, 2009
Human skin cells exposed to the ozone in smog exhibit changes in signaling pathways that put them at increased risk for developing cancer.
