Study: Psoriasis and Colorectal Cancer Association

An article the in Journal of the American Academy of Dermatology examined the possible connection between psoriasis and colorectal cancer.

The relation between psoriasis and colorectal cancer (CRC) is not yet clear, but nowin a recent study, researchers for the Journal of the American Academy of Dermatology (JAAD) have investigated the association.

A systematic review and meta-analysis conducted on the observation studies examined the association of psoriasis with CRC. Both MEDLINE and Embase was searched on March 24, 2020, for relevant studies and the Newcastle-Ottawa scale was utilized to evaluate the risk of bias of the included studies. After, a random-effects model meta-analysis and subgroup analysis was conducted according to sex.

In total, 9 cohort studies with 10,544,609 subjects were included. A significantly increased risk for CRC in patients with psoriasis was discovered (hazard ratio [HR], 1.16; 95% confidence interval [CI], 1.08-1.24). Also, the subgroups analysis according to sex found significantly increased risk for CRC in female patients with psoriasis (HR, 1.41; 95% CI, 1.16-1.72) but not in male patients (HR, 1.18; 95% CI, 0.92-1.50), according to researchers. The data was limited by the lack of information on psoriatic arthritis.

The researchers concluded that patients with psoriasis have an increased risk for CRC:“Gastroenterology consultation and colonoscopic examination are indicated for patients with psoriasis presenting with bowel symptoms.”

Reference:

Fu Y, Lee CH, Chi CC. Association of psoriasis with colorectal cancer. Journal of the American Academy of Dermatology. 2021;85(6):1429-1436. doi:10.1016/j.jaad.2020.09.050