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Maui, Hawaii - Nodal staging with sentinel lymph node biopsy (SLN) is warranted in all patients with malignant melanoma at risk for nodal metastasis, and patients with a positive SLN should undergo therapeutic lymph-node dissection and be counseled about the opportunity for adjuvant therapy with interferon alfa-2b (Intron A) or participation in ongoing clinical trials, Kelly M. McMasters, M.D., Ph.D, said at the annual Hawaii Dermatology Seminar, sponsored by the Skin Disease Education Foundation.