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Roflumilast Itch Response for Plaque Psoriasis Treatment


Linda Stein Gold, MD, discusses the itch response of roflumilast for the treatment for plaque psoriasis.

Jennifer Soung, MD: Let’s take a look at roflumilast and its itch response. I like to tell patients that they’re starting to see a response, or knowing that the topical is working since they can notice an itch relief as early as week 2. When we look at the data, you’re looking at approximately 67% of patients having at least a 4-point improvement in their itch score at week 8. That’s meaningful when you have plaque in a sensitive area and it’s really bothersome. Imagine plaque in the fold areas underneath the breast or in the genital area where you need that symptom relief.

LindaStein Gold, MD: I agree, especially due to the fact that it kicks in and we do see separation early on. As you mentioned by the end of week 8, about two-thirds of those patients have that 4-grade improvement in the itch, which is a very meaningful improvement. We always ask our atopic patients, “How’s your itching?” We must make sure that we ask our patients with psoriasis as well.

Jennifer Soung, MD: We’ve talked a lot about sensitive areas like the face, underarms and genitals. Does this topical work for those really thick areas like the knees, or elbows?

Transcript edited for clarity

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