Why do biologics lose efficacy over time? This physician discusses factors dermatologists should consider when they see this issue in their patients.
With many patients, real-world factors frequently interfere with a drug’s performance. Dermatologists may especially see this happen when prescribing biologic therapies. (©ClaudiaPlyinskaya/Shutterstock.com)
Identifying the right medication for a patient with a skin condition can often be difficult. But even pinpointing the right treatment doesn’t mean it will work equally as well over time.
With many patients, real-world factors frequently interfere with a drug’s performance. Dermatologists may especially see this happen when prescribing biologic therapies.
“It’s a very frequent issue for biologics to, after the initial response, lose efficacy,” said Stephen Wolverton, M.D., professor of dermatology at the Indiana University School of Medicine. “So, it’s important for dermatologists to know that there are antibodies to drugs or factors, such as the loading dose versus maintenance dose frequency, can impact efficacy.”
Dr. Wolverton discussed these various factors that could reduce a drug’s efficacy over time during the American Academy of Dermatology Annual Meeting in Washington, D.C. These are factors, he said, that can affect drug efficacy:
Overall, Wolverton said, more clinical trials are needed to determine the largest influences over the appearance of anti-drug antibodies. This knowledge could impact how dermatologists decide to change dosing or reduce frequency.
S029 - Controversies and Difficult Questions Concerning Biologic Therapeutics. “Some reasons which biologics lose efficacy over time in the real world.” Stephen Wolverton, M.D., 1-4p.m., March 2, American Academy of Dermatology Annual Meeting 2019.