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National report — Patients with periorbital wrinkles can benefit from ablative treatments with a new plasma-based system.
National report - Patients with periorbital wrinkles can benefit from ablative treatments with a new plasma-based system.
In a recent study, researchers used the PSR system to treat 10 patients with Fitzpatrick skin types I through III who suffered from periorbital rhytids. Researchers gave patients one to two passes (at 1.5 to 3.5 J/cm2) of nonoverlapping pulses, with clinical assessments performed at baseline and at a series of follow-up visits. These were scheduled at 10 days, one month, three months and six months after the procedure.
At days 10 and 30, all patients showed at least 30 percent to 50 percent improvement in skin texture and the severity of periorbital rhytids. Researchers subsequently observed additional improvement.
"There was a significant, dramatic improvement in the number of periorbital wrinkles. The skin texture was much smoother. All patients had completely re-epithelialized skin by day 10. Most patients had no significant erythema between 14 and 20 days after the surgery, which is far better than one would expect with a CO2 laser using the same energy parameters. So the photobiologic effect of PSR seems to be quite superior in terms of side effect profile and clinical efficacy," he says.
As in previous tests of the equipment, researchers observed that immediately after treatment, the epidermis remained intact. However, some redness and edema of the skin eventually developed, peaking at about 48 hours post-treatment.
After that point, Dr. Tremblay says, "The epidermis was sloughed off, and new skin started forming on the smooth dermal wound."
Researchers credit the biologic dressing created by the epidermis for significantly increasing patients' rate of healing and decreasing the intensity of their erythema. They also believe the epidermal "dressing" accounts for patients' mild side effect profiles, which included pain, pruritus and postoperative erythema.
For now, he says, "The PSR system is a very interesting and useful tool because it can be used for both ablative and nonablative purposes. It offers quite a bit of flexibility. One can tailor the treatment parameters to patient-specific needs. It's a tool that most dermatologists would benefit from having in their practices."
What makes PSR unique is its plasma energy source.
"The plasma is generated by the excitation of a nitrogen gas using electromagnetic energy," he explains. "Plasma is a combination of heat and non-coherent light energy that has a unique photothermal effect on the skin." Further testing, he adds, should allow researchers to better understand the product's mechanism of action and further optimize its results.
Disclosure: Gyrus Medical lent Dr. Tremblay and Ronald Moy, M.D., the PSR system for use in this study. However, they report no financial interests in the company.
For more information: http://www.gyrusmed.com/