Three studies point to links between rosacea and numerous systemic comorbid diseases.
Researchers report in a study1 published online September 7, 2016, in the British Journal of Dermatology, that they examined the same cohort as Alexander Egeberg, M.D., Ph.D., department of dermatology and allergy, Herlev and Gentofte Hospital, Hellerup, Denmark and coauthors, and found rosacea constitutes an independent risk factor for Parkinson disease.
Dr. Egeberg and colleagues found in another study2 published earlier this year that rosacea is associated with type 1 diabetes mellitus, celiac disease, multiple sclerosis and rheumatoid arthritis in women. The association in men between rosacea and those diseases was only statistically significant for rheumatoid arthritis. That was a study in 6759 patients with rosacea and 33,795 matched controls.
A small study3 published October 2015 in the Journal of the American Academy of Dermatology suggests significant associations between rosacea and numerous systemic comorbid diseases in a skin severity-dependent manner. The researchers studied 130 subjects, including 65 rosacea patients and 65 controls. They found significant associations between rosacea and allergies, respiratory diseases, gastroesophageal reflux disease, other gastrointestinal diseases, hypertension, metabolic and urogenital diseases and female hormone imbalance.
1 – Egeberg A, Hansen PR, Gislason G, et al; Exploring the association between rosacea and Parkinson Disease; a Danish cohort study. JAMA Neurol.2016;73(5):529-534.
2 – Egeberg A, Hansen PR, Gislason GH, Thyssen JP. Clustering of autoimmune diseases in patients with rosacea. J Am Acad Dermatol. 2016 Apr;74(4);667-672
3 – Rainer BM, Fischer AH, Luz Felipe da Silva D, Kang S, Chien AL. Rosacea is associated with chronic systemic diseases in a skin severity-dependent manner: Results of a case-control study. J Am Acad Dermatol. 2015 Oct;73(4): 604-608.