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Recently, a group of leading dermatologists, clinical investigators, and dermasurgeons met to discuss the role of 5-fluorouracil (5-FU) in their practices. The experts discussed a new treatment paradigm for actinic keratosis (AK) and how it is changing. They also shared their personal experiences in using 5-FU innovatively to treat AK, while reducing inflammation and discomfort and improving compliance. In addition, the physicians reviewed the use of 5-FU in the treatment of several other dermatologic conditions, such aswarts and actinic cheilitis.