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Commemorating Dermatology Times’ 45th Anniversary

Dermatology TimesDermatology Times, July 2024 (Vol. 45. No. 07)
Volume 45
Issue 07

Explore dermatology's history and the journey through our publication's 45 years of covering an ever evolving specialty.

Dermatology Times 45th Anniversary logo

As Dermatology Times celebrates its 45th anniversary, we invite you to join us on a journey through the most impactful milestones in dermatology’s history. Over the decades, advancements in clinical practices, groundbreaking treatments, and innovative technologies have revolutionized the specialty, benefiting both practitioners and patients alike. In this special edition, we gain invaluable insights from our esteemed editorial advisory board on the influential people, pivotal drugs, and cutting-edge technologies that have shaped dermatology.

Hippocrates | Image Credit: © acrogame - stock.adobe.com

Hippocrates | Image Credit: © acrogame - stock.adobe.com

460-370 BC

Hippocrates, often called the father of modern medicine, proposes classifying skin diseases and treated them with honey, tar, and fats, based on humoral theory.1


Henry Daggett Bulkley, MD, the first US dermatologist, opened the Broome Street Infirmary for Diseases of the Skin in New York, New York.2


Alexander John Balmanno Squire used photography for the first time to document skin diseases.1


Niels Ryberg Finsen pioneered the use of UV radiation for treating lupus vulgaris, winning the Nobel Prize in Medicine in 1903.1

Dr Frederic Edward Mohs | Image Credit: American College of Mohs Surgery

Dr Frederic Edward Mohs | Image Credit: American College of Mohs Surgery


Frederic Edward Mohs develops the Mohs micrographic surgery technique and uses it for the first time on a patient with squamous cell cancer of the lower lip.3


The American Academy of Dermatology (AAD) was founded; today, it is headquartered in Rosemont, Illinois and has grown to more than 20,000 members.4


Topical corticosteroid (hydrocortisone) was first developed; it is used in treating inflammation and itching due to various skin conditions.5


The first issue of Dermatology Times is published to o er clinical insights for a growing health care specialty.


An article in the Journal of the American Academy of Dermatology points out the growth of academic dermatologists in the US from 381 to 511 from 1976 to 1980.6


The FDA approves PUVA (psoralen and UV-A) for the treatment of psoriasis and isotretinoin (Accutane) for the treatment of severe acne.7-8


The FDA approves aciclovir (Zovirax) for the treatment of genital herpes simplex infection.9


Etretinate (Tegison) is approved for the treatment of psoriasis and used off-label for the treatment of generalized pustular psoriasis and palmar-plantar pustular psoriasis.10


Minoxidil (Rogaine) is FDA-approved for treating hair loss.11 Darrell S. Rigel, MD, attends the AAD Annual Meeting and presents 2 new regions identified with populations at high risk for melanoma—US east and west coastlines and areas of substantial elevation.12

Generic vintage 1990s style computer | Image Credit: © Destina - stock.adobe.com

Image Credit: © Destina - stock.adobe.com


Dermatology Times featured practice management pearls on the introduction of computers to reduce paperwork and increase efficiency.


One study shows onabotulinumtoxinA (Botox) improves glabellar frown lines and was approved in 2002.13Tattoo removals using the ruby laser grow in popularity.14 Teledermatology begins to consult and military personnel on missions.15

Tattoo removal laser | Image Credit: © natatravel - stock.adobe.com

Image Credit: © natatravel - stock.adobe.com


The Nd:YAG laser is approved to treat pigmented lesions.16 A new nationwide database provides access to information on sexually transmitted diseases.17


Dermatologists’ growing role in the management of AIDS was a hot topic.18 Congress allocated $1.2 million for the promotion of the AAD’s melanoma and skin cancer education program.19 The alexandrite laser for tattoo removal and copper bromide laser are approved for vascular and pigmented lesions.20-21


Imiquimod (Aldara) is approved to treat external genital warts, and later in 2004 for actinic keratosis and superficial basal cell carcinoma.22


Tacrolimus (Protopic) is approved to treat moderate to severe atopic dermatitis.23 Botulinum toxin type B (Myobloc) is approved for the treatment of cervical dystonia, later used off-label for cosmetic purposes.24


Pimecrolimus (Elidel) is approved for the treatment of mild to moderate atopic dermatitis.25


Hyaluronic acid fillers (Restylane) gain FDA approval for facial wrinkles and folds.26


Poly-L-lactic acid (Sculptra) is approved for lipoatrophy in patients with HIV.27


The FDA approves adalimumab (Humira) for the treatment of moderate to severe chronic plaque psoriasis.28


Collagenase clostridium histolyticum (Xiaflex) is approved for the treatment of Dupuytren contracture, and later for Peyronie disease.29


Vemurafenib is approved by the FDA for metastatic and unresectable melanomas.30


The FDA approves tazarotene (Tazorac) for the treatment of acne vulgaris in patients 12 years and older and vismodegib (Erivedge) for advanced and metastatic basal cell carcinoma.31-32


Ustekinumab (Stelara) is FDA-approved for adults with active psoriatic arthritis.33


The FDA approves apremilast (Otezla) for adults with active psoriatic arthritis and efinaconazole (Jublia) for onychomycosis.34-35


Secukinumab (Cosentyx) is approved for adults with moderate to severe plaque psoriasis.36


Crisaborole (Eucrisa) is FDA-approved for atopic dermatitis, and ixekizumab (Taltz) is also approved for the treatment of moderate to severe plaque psoriasis in adults.37-38


The FDA approves brodalumab (Siliq) for moderate to severe plaque psoriasis, tofacitinib (Xeljanz) for psoriatic arthritis, and dupilumab (Dupixent) for moderate to severe atopic dermatitis.39-41


The FDA approves sarecycline hydrochloride (Seysara) for nonnodular acne vulgaris and tildrakizumab (Ilumya) for moderate to severe plaque psoriasis.42-43


Biosimilars in dermatology continue to garner interest 10 years after the first was approved, as they offer equally effective, safe, and cost-effective options for patients.44 Trifarotene (Aklief) was approved for acne vulgaris treatment.45


The FDA approves topical minocycline foam for rosacea lesions, collagenase clostridium histolyticum-aaes for moderate to severe cellulite in the buttocks, clascoterone cream 1% (Winlevi) for moderate to severe hormonal acne, tirbanibulin (Klisyri) for actinic keratosis, and adapalene gel 0.3% was launched in the US for acne vulgaris.46-50


Research on the connections between skin diseases and COVID-19 begins to emerge, indicating that patients with inflammatory skin conditions and associated comorbidities are at increased risk for the virus.51


The FDA approved abrocitinib (Cibinqo) for the treatment of moderate to severe atopic dermatitis, tapinarof (Vtama) for the treatment of plaque psoriasis in adults, spesolimab (Spevigo) for the treatment of generalized pustular psoriasis, and ruxolitinib cream (Opzelura) for the treatment of nonsegmental vitiligo.52-55


The FDA approves numerous adalimumab biosimilars, beremagene geperpavec (Vyjuvek) for dystrophic epidermolysis bullosa, bimekizumab (Bimzelx) for moderate to severe plaque psoriasis, Cantharidin (YCanth) to treat mulluscum contagiosum, nivolumab (Opdivo) for completely resected stage IIB or IIC melanoma, ritlecitinib (Litfulo) for patients 12 and up with severe alopecia areata, roflumilast cream 0.3% for children 6 to 11 years old with plaque psoriasis, secukinumab (Cosentyx) for moderate to severe hidradenitis suppurativa, tralokinumab (Adbry) for moderate to severe atopic dermatitis in patients 12 and older, and roflumilast foam 0.3% (Zoryve) for seborrheic dermatitis. Clindamycin phosphate 1.2%, adapalene 0.15%, benzoyl peroxide 3.1%; gel (Cabtreo) was also approved for acne.56

In aesthetics, Galderma’s Restylane Eyelight is approved for the treatment of undereye hollows in adults older than 21 years. Skinvive by Juvéderm is approved for improving skin smoothness in adults 21 years and older.56

2024 Berdazimer gel 10.3% (Zelsuvmi) is approved for the treatment of molluscum contagiosum. Tralokinumab’s autoinjector is also approved for adults with moderate to severe atopic dermatitis.57-58


  1. Ferreira IG, Weber MB, Bonamigo RR. History of dermatology: the study of skin diseases over the centuries. An Bras Dermatol. 2021;96(3):332-345. doi:10.1016/j.abd.2020.09.006
  2. Cipollaro AC. Henry Daggett Bulkley, 1804 to 1872:pioneer American dermatologist. Arch Dermatol. 1969;99(5):521-528.
  3. History of Mohs surgery. American College of Mohs Surgery. Accessed June 19, 2024. https://www.mohscollege.org/about-acms/history-of-mohs-surgery
  4. About theacademy. American Academy of Dermatology Association. Accessed June 19, 2024. https://www.aad.org/about-aad
  5. Hoare C, Li Wan Po A, Williams H. Chapter 4: Topical corticosteroids. In: Systematic Review of Treatments for Atopic Eczema. NIHR Journals Library; 2000. https://www.ncbi.nlm.nih.gov/books/NBK260250/
  6. Everett MA. Dermatologists in academia: 1980. J Am Acad Dermatol. 1981;4(3):346-347. doi:10.1016/s0190-9622(81)80179-x
  7. Cather J, Menter A. Novel therapies for psoriasis. Am J Clin Dermatol. 2002;3(3):159-173. doi:10.2165/00128071-200203030-00003
  8. Pile HD, Sadiq NM. Isotretinoin. In: StatPearls. StatPearls Publishing; 2023.
  9. Chou S. Advances in antiviral therapy. J Invest Dermatol. 1984;83(suppl 1):116s-120s. doi:10.1111/1523-1747.ep12281839
  10. Etretinate approved. FDA Drug Bull. 1986;16(2):16-17.
  11. Minoxidil: formulation, dosage and side-effects. International Society of Hair Restoration Surgery. Accessed June 19, 2024. https://ishrs.org/patients/treatments-for-hair-loss/medications/minoxidil/
  12. Rigel DS, Friedman RJ, Kopf AW. The incidence of malignant melanoma in the United States: issues as we approach the 21st century. J Am Acad Dermatol. 1996;34(5 pt 1):839-847. doi:10.1016/s0190-9622(96)90041-9
  13. Park MY, Ahn KY. Scientific review of the aesthetic uses of botulinum toxin type A. Arch Craniofac Surg. 2021;22(1):1-10. doi:10.7181/acfs.2021.00003
  14. Wheeland RG. Tattoo removal using the ruby laser. West J Med. 1992;156(2):190.
  15. Tommasino N, Megna M, Cacciapuoti S, et al. The past, the present and the future of teledermatology: a narrative review. Clin Cosmet Investig Dermatol. 2024;17:717-723.doi:10.2147/CCID.S462799
  16. Hruza GJ, Geronemus RG, Dover JS, Arndt KA. Lasers in dermatology—1993. Arch Dermatol. 1993;129(8):1026-1035. doi:10.1001/archderm.1993.01680290098017I
  17. Aral SO, Fenton KA, Holmes KK. Sexually transmitted diseases in the USA: temporal trends. Sex Transm Infect. 2007;83(4):257-266. doi:10.1136/sti.2007.026245
  18. Milbar H, James WD. The role of dermatologists in the early HIV/AIDS epidemic: a historical review for the 40th anniversary of HIV/AIDS. JAMA Dermatol. 2021;157(3):326-329. doi:10.1001/jamadermatol.2020.5545
  19. Skin cancer primary prevention education projects; amendment. Fed Regist. 1994;59(118).Accessed June 19, 2024. https://www.federalregister.gov/documents/1994/06/21/94-15009/skin-cancer-primary-prevention-education-projects-amendment
  20. Fitzpatrick RE, Goldman MP. Tattoo removal using the alexandrite laser. Arch Dermatol. 1994;130(12):1508-1514.
  21. McCoy SE. Copper bromide laser treatment of facial telangiectasia: results of patients treated over five years. Lasers Surg Med. 1997;21(4):329-340. doi:10.1002/(sici)1096-9101(1997);21(4):329-340. doi:10.1002/(sici)1096-9101(1997)21:4<329::aid-lsm4>3.0.co;2-s
  22. Bubna AK. Imiquimod - its role in the treatment of cutaneous malignancies. Indian J Pharmacol. 2015;47(4):354-359. doi:10.4103/0253-7613.161249
  23. Cury Martins J, Martins C, Aoki V, Gois AF, Ishii HA, da Silva EM. Topical tacrolimus for atopic dermatitis. Cochrane Database Syst Rev. 2015;2015(7):CD009864. doi:10.1002/14651858.CD009864.pub2
  24. Spiegel LL, Ostrem JL, Bledsoe IO. FDA approvals and consensus guidelines for botulinum toxins in the treatment of dystonia. Toxins (Basel). 2020;12(5):332. doi:10.3390/toxins12050332
  25. Bernard LA, Bergman JN, Eichenfield LF. Pimecrolimus 1% cream (Elidel) for atopic dermatitis. Skin Therapy Lett. 2002;7(4):1-3.
  26. Brandt FS, Cazzaniga A. Hyaluronic acid gel fillers in the management of facial aging. Clin Interv Aging. 2008;3(1):153-159. doi:10.2147/cia.s2135
  27. Borelli C, Kunte C, Weisenseel P, Thoma-Greber E, Korting HC, Konz B. Deep subcutaneous application of poly-L-lactic acid as a filler for facial lipoatrophy in HIV-infected patients. Skin Pharmacol Physiol. 2005;18(6):273-278. doi:10.1159/000087608
  28. Alwawi EA, Mehlis SL, Gordon KB. Treating psoriasis with adalimumab. Ther Clin Risk Manag. 2008;4(2):345-351. doi:10.2147/tcrm.s1265
  29. Lehrman JD, Miceli ALL, Tabchi SG, Kaplan MA. The effects of collagenase Clostridium histolyticum on plantar fibromatosis: a case study. J Foot Ankle Surg. 2019;58(6):1281-1284. doi:10.1053/j.jfas.2019.04.006
  30. Kim G, McKee AE, Ning YM, et al. FDA approval summary: vemurafenib for treatment of unresectable or metastatic melanoma with the BRAFV600E mutation. Clin Cancer Res. 2014;20(19):4994-5000. doi:10.1158/1078-0432.CCR-14-0776
  31. Gregoriou S, Kritsotaki E, Katoulis A, Rigopoulos D. Use of tazarotene foam for the treatment of acne vulgaris. Clin Cosmet Investig Dermatol. 2014;7:165-170. doi:10.2147/CCID.S37327
  32. Fellner C. Vismodegib (Erivedge) for advanced basal cell carcinoma. P T. 2012;37(12):670-682.
  33. Davari P, Leo MS, Kamangar F, Fazel N. Ustekinumab for the treatment of psoriatic arthritis: an update. Clin Cosmet Investig Dermatol. 2014;7:243-249. doi:10.2147/CCID.S50003
  34. Fala L. Otezla (apremilast), an oral PDE-4 inhibitor, receives FDA approval for the treatment of patients with active psoriatic arthritis and plaque psoriasis. Am Health Drug Benefits. 2015;8(spec feature):105-110.
  35. Lipner SR, Scher RK. Efinaconazole in the treatment of onychomycosis. Infect Drug Resist. 2015;8:163-172. doi:10.2147/IDR.S69596
  36. Fala L. Cosentyx (secukinumab): first IL-17A antagonist receives FDA approval for moderate-to-severe plaque psoriasis. Am Health Drug Benefits. 2016;9(spec feature):60-63.
  37. Fahrbach K, Tarpey J, Washington EB, et al. Crisaborole ointment, 2%, for treatment of patients with mild-to-moderate atopic dermatitis: systematic literature review and network meta-analysis. Dermatol Ther (Heidelb). 2020;10(4):681-694. doi:10.1007/s13555-020-00389-5
  38. Markham A. Ixekizumab: first global approval. Drugs. 2016;76(8):901-905. doi:10.1007/s40265-016-0579-y
  39. Galluzzo M, D’Adamio S, Massaro A, Piccolo A, Bianchi L, Talamonti M. Spotlight on brodalumab in the treatment of plaque psoriasis: the evidence to date. Clin Cosmet Investig Dermatol. 2019;12:311-321.doi:10.2147/CCID.S165605
  40. Ly K, Beck KM, Smith MP, Orbai AM, Liao W. Tofacitinib in the management of active psoriatic arthritis: patient selection and perspectives. Psoriasis (Auckl). 2019;9:97-107. doi:10.2147/PTT.S161453
  41. Shirley M. Dupilumab: first global approval. Drugs. 2017;77(10):1115-1121. doi:10.1007/s40265-017-0768-3
  42. Kaul G, Saxena D, Dasgupta A, Chopra S. Sarecycline hydrochloride for the treatment of acne vulgaris. Drugs Today (Barc). 2019;55(10):615-625. doi:10.1358/dot.2019.55.10.3045040
  43. Markham A. Tildrakizumab: first global approval. Drugs. 2018;78(8):845-849. doi:10.1007/s40265-018-0917-3
  44. Constantin MM, Cristea CM, Taranu T, et al. Biosimilars in dermatology: the wind of change. Exp Ther Med. 2019;18(2):911-915. doi:10.3892/etm.2019.7505
  45. Brumfiel CM, Patel MH, Bell KA, Cardis MA. Assessing the safety and efficacy of trifarotene in the treatment of acne vulgaris. Ther Clin Risk Manag. 2021;17:755-763. doi:10.2147/TCRM.S286953
  46. Menlo Therapeutics receives FDA approval of ZILXI (minocycline) topical foam, 1.5%, the first topical minocycline treatment for rosacea. News release. Menlo Therapeutics. May 29, 2020. Accessed June 19, 2024. http://ir.menlotherapeutics.com/news-releases/news-release-details/menlo-therapeutics-receives-fda-approval-zilxitm-minocycline
  47. Graivier M, Hill D, Katz B, Boehm KA, Fisher J, Battista C. Collagenase Clostridium histolyticum for the treatment of cellulite in the buttocks and thigh: early insights from clinical practice. Aesthet Surg J Open Forum. 2022;4:ojac057. doi:10.1093/asjof/ojac057
  48. Petronelli M. Topical androgen receptor inhibitor approved by FDA for acne. Dermatology Times. August 28, 2020. Accessed June 19, 2024. https://www.dermatologytimes.com/view/topical-androgen-receptor-inhibitor-approved-by-fda-for-acne
  49. Petronelli M. Alembic Pharmaceuticals launches adapalene gel for acne vulgaris. Dermatology Times. September 1, 2020. Accessed June 19, 2024. https://www.dermatologytimes.com/view/alembic-pharmaceuticals-launches-adapalene-gel-for-acne-vulgaris
  50. Dao DD, Sahni VN, Sahni DR, Balogh EA, Grada A, Feldman SR. 1% tirbanibulin ointment for the treatment of actinic keratoses. Ann Pharmacother. 2022;56(4):494-500. doi:10.1177/10600280211031329
  51. Patrick MT, Zhang H, Wasikowski R, et al. Associations between COVID-19 and skin conditions identified through epidemiology and genomic studies. J Allergy Clin Immunol. 2021;147(3):857-869.e7. doi:10.1016/j.jaci.2021.01.006
  52. Perche PO, Cook MK, Feldman SR. Abrocitinib: a new FDA-approved drug for moderate-to-severe atopic dermatitis. Ann Pharmacother. 2023;57(1):86-98. doi:10.1177/10600280221096713
  53. Spencer RK, Jin JQ, Elhage KG, Davis MS, Liao W, Bhutani T. Management of plaque psoriasis in adults: clinical utility of tapinarof cream. Psoriasis (Auckl). 2023;13:59-69. doi:10.2147/PTT.S393997
  54. Blair HA. Spesolimab: first approval. Drugs. 2022;82(17):1681-1686. doi:10.1007/s40265-022-01801-4
  55. Hu W, Thornton M, Livingston RA. Real-world use of ruxolitinib cream: safety analysis at 1 year. Am J Clin Dermatol. 2024;25(2):327-332.
  56. Buchanan L, Bader K, Andrus E. Check your list and consider it twice: a recap of 2023 drug approvals. Dermatology Times. December 18, 2023. Accessed June 19, 2024. https://www.dermatologytimes.com/view/check-your-list-and-consider-it-twice-a-recap-of-2023-drug-approvals
  57. Andrus E. FDA approves berdazimer gel, 10.3% for the treatment of molluscum contagiosum. Dermatology Times. January 5, 2024. Accessed June 19, 2024. https://www.dermatologytimes.com/view/fda-approves-berdazimer-gel-10-3-for-the-treatment-of-molluscum-contagiosum
  58. Andrus E. FDA approves tralokinumab autoinjector for adults with moderate to severe atopic dermatitis. Dermatology Times. June 13, 2024. Accessed June 19, 2024.
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