New Orleans - Jean and Alistair Carruthers, M.D.s, who , in 1991, introduced botulinum for treatment of frown lines second American Society of Dermatologic Surgeons (ASDS) predictions of the neurotoxin's widening role in 2004. These include: enhancing upper lip fullness, treating enlarged masseter muscles, contouring the mandible area of the lower face, and eliminating multiple benign cystic lesions of the face. Dr. Jean Carruthers confirmed the society's predictions and appended her own.