• Dry Cracked Skin
  • Impetigo
  • Aesthetics
  • Vitiligo
  • COVID-19
  • Actinic Keratosis
  • Precision Medicine and Biologics
  • Rare Disease
  • Wound Care
  • Rosacea
  • Psoriasis
  • Psoriatic Arthritis
  • Atopic Dermatitis
  • Surgery
  • Melasma
  • NP and PA
  • Anti-Aging
  • Skin Cancer
  • Hidradenitis Suppurativa
  • Drug Watch
  • Pigmentary Disorders
  • Acne
  • Pediatric Dermatology
  • Practice Management
  • Inflamed Skin

Botanical Blend Demonstrates Efficacy in New Anti-Aging Study


The combination of punica granatum, citrus sinesis, f. cistanche, and centella asiatica revealed improved skin moisturization, radiance, and elasticity in a new study.


A new clinical study supports powerful anti-aging skin benefits of Eternalyoung® (EY), from Monteloeder, S. L., a subsidiary of Suanfarma. The blend of 4 botanical extracts includes punica granatum (pomegranate), citrus sinesis (orange), f. cistanche (desert ginseng), and centella asiatica (gotu kola).1

The research, led by Vincenzo Nobile, PhD, at the Complife Italia Srl in Pavia, Italy, consisted of a randomized, double-blind, placebo-controlled study of 60 women aged 35 to 69, all of whom exhibited signs of both sun-induced and chronological skin aging, specifically mild to moderate wrinkles and dark spots. It included healthy subjects with skin phototypes from I to IV who were willing to avoid both natural and artificial ultraviolet (UV) radiation.

The participants consumed a hard gelatin capsule of 225mg of the Eternalyoung complex or a placebo every day for 12 weeks. Investigators analyzed several parameters of skin health: skin moisturization, skin elasticity, transepidermal water loss (TEWL), skin thickness, dark spot staining, skin radiance, and skin profilometry. including wrinkle depth, elasticity, firmness, skin thickness, moisturization, water loss, and dark spot pigmentation, and observed improvements as early as 4 weeks.

Subjects who consumed the botanical blend reported significant skin improvement and less stress and fatigue. Study authors said this leads them to conclude that the blend has the ability to promote overall well-being

The study, published in Cosmetics, was conducted so investigators could further investigate plant polyphenols after previous studies showed the same extracts revealed anti-aging effects in a dermal fibroblast cell model.

 Investigators noted several study limitations, such as the subjects all being females with Caucasian skin. They said further studies are needed to determine whether the product would produce the same benefits in other ethnic skin types or among men.


1. Nobile, V.; Schiano, I.; Germani, L.; Cestone, E.; Navarro, P.; Jones, J.; Caturla, N. Skin Anti-Aging Efficacy of a Four-Botanical Blend Dietary Ingredient: A randomized, double blind, clinical study. Cosmetics. 2023, 10 (1): 16. DOI: 10.3390/cosmetics10010016

Related Videos
© 2024 MJH Life Sciences

All rights reserved.