Newer treatment approaches may soon become mainstream in the treatment and management of keloids, one expert says.
Keloids have always been challenging to treat with therapeutic modalities of varying efficacy, ranging from traditional surgical techniques and radiation, to relatively less invasive modalities including intralesional and topical therapies, such as corticosteroids and 5-fluorouracil, among others.
“Several of the treatment approaches that are currently used for keloids do not achieve satisfactory outcomes and are fraught with high recurrence rates as well as poor treatment responses in many cases,” says Somesh Gupta, M.D., DNB, department of dermatology and venerology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India. “This therapeutic vacuum has generated much interest in new and experimental treatment techniques that have shown to be very effective in the treatment and management of keloids.”
However, the precise etiology of keloids largely remains unknown from a therapeutic standpoint. Dr. Gupta says that many people consider keloids as a local tumor with a very high recurrence rate.
This is why chemotherapy is often used in the form of 5-fluorouracil and bleomycin. According to Dr. Gupta, keloids are also considered to be an inflammatory lesion because they are often associated with itching, inflammation and pain, as well as an increase in keloidal in ammatory markers.
This is also why the treatment with anti-inflammatory agents such as corticosteroids when administered intralesionally has seen good success in keloid therapy.