Washington - Attempts to explain the aging process at the cellular level have identified two main culprits - intrinsic aging and photoaging. "When referring to the skin," said Mina Yaar, M.D., "it's important to differentiate between intrinsic or chronologic aging that comprises the clinical, histologic, and physiologic changes in sun-protected skin, and photoaging, defined as the clinical, histologic, and physiologic changes in habitually sun-exposed skin." She is professor of dermatology at Boston University School of Medicine. Dr. Yaar will speak on molecular mechanisms in aging and photoaging at the AAD meeting scheduled here February 6-11.
LEO Pharma has closed its acquisition of dersimelagon from Tanabe Pharma after the FDA accepted the drug's NDA for filing and granted Priority Review, with a PDUFA date expected by the end of February 2027.
Sol-Gel Technologies has completed patient follow-up in its pivotal phase 3 trial of SGT-610 (patidegib gel, 2%) for Gorlin syndrome, with top-line results expected in late November 2026.
Longer treatment duration was independently associated with VASI improvement, while publicly insured patients experienced higher topical JAK inhibitor denial rates.
Though convenient, SPF-infused cosmetics rarely deliver their labeled protection level in real-world use, underscoring the continued need for a dedicated broad-spectrum sunscreen as the foundation of any routine.